Metallothioneins (MT) are low-molecular weight proteins implicated in heavy metal detoxification, zinc and cooper homeostasis and cell protection against free radicals. In variety of cancers MT-overexpression was shown, but there are just a few studies on the role of MT in skin carcinogenesis. Current study was undertaken to evaluate MT and Ki-67 expression in pre-cancerous skin lesions as well as in fully developed skin cancers. 73 squamous cell carcinomas (SCC), 23 actinic keratoses (AK) and 20 normal skin samples were included in the study. In obtained paraffin sections immunohistochemical reactions were performed. MT-expression in SCC (mean 2.89 ± 1.83) was significantly higher than in AK (mean 1.69 ± 1.26)(p = 0.006) and higher than in normal skin (mean 2 ± 0.79) (p = 0.0075). The MT-expression positively correlated with Ki-67 expression (R = 0.28; p = 0.017) in SCC and in AK (R = 0.49; p = 0.018). Various clinico-pathological variables, e.g. morphology, size of lesions and the depth of neoplastic infiltration were not associated to MT-expression in both SCC and AK. The grade of histological differentiation of SCC correlated positively with Ki-67 antigen (p < 0.001) and did not correlate with MT-expression (p = 0.06). Ki-67 expression was higher in SCC and in AK than in healthy skin (p = 0,003). In SCC and in AK expression of Ki-67 antigen correlated positively with MT-expression (respectively p = 0.017 and p = 0.018). MT may serve as a good markers of proliferation in SCC and AK. MT-overexpression in SCC may suggest a potential role of MT in skin carcinogenesis.
The Brooke-Spiegler syndrome is an autosomal dominant one characterized by cylindromas, trichoepitheliomas and occasionally spiradenomas. Within a given family, some members may have cylindromas whereas others may have trichoepitheliomas or both. We describe the coexistence of trichoepithelioma papulosum multiplex (also known as epithelioma adenoides cysticum of Brooke) and cylindromas in a 30-year-old man, and discuss the relationship between these two autosomal dominant syndromes.
Background Toxic epidermal necrolysis (TEN) is a severe, life-threatening disease wiih many sitnilarities to graft-versushost disease (GVHD), Although the pathogenesis of TEN is still unclear, it is widely accepted that TEN is an itnmiinologicaily mediated disease. The treatment of TEN is often unsatisfactory, Cyclosporin was demonstrated to affect the early phase of Tcell activaiiun and was recently shown to be effective in GVHD,Observations Three cases of TEN were treated with 8-10 mg/kg/day cyclosporin in conjunctioti with corticosteroids, CycUisporin therapy was continued for 10-21 days, depending on the severity of the disease. Rapid improvement in skin condition was observed in all patients; skin and mucous lesions healed completely after this treatment.Conclusions Our findings suggest that cyclosporin can have a beneticial effect in TEN. and should be considered as treatment of choice in the early phase of TEN to arrest primary immunopalhological processes. © Elsevier Science B.V, 22.'i415, 0926-9959/97/$ 17,00 © Elsevier Science B,V, All rights reserved Pfl S0926-9959(97)()0()47-0
The Brooke-Spiegler syndrome is an autosomal dominant one characterized by cylindromas, trichoepitheliomas and occasionally spiradenomas. Within a given family, some members may have cylindromas whereas others may have trichoepitheliomas or both. We describe the coexistence of trichoepithelioma papulosum multiplex (also known as epithelioma adenoides cysticum of Brooke) and cylindromas in a 30-year-old man, and discuss the relationship between these two autosomal dominant syndromes.
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