The use of rhTSH avoids the debilitating effects of hypothyroidism and its use successfully promotes iodine uptake and increases the sensitivity of serum Tg testing. The risk of causing serious side-effects recommends performing skull magnetic resonance and radionuclide bone scan in cases of suspected brain or skeletal metastases.
The follow-up of Differentiated Thyroid Cancer conventionally includes serum thyroglobulin and periodic Whole Body Scans. The uptake of 131-I in normal and pathological tissues different from metastatic thyroid cancer sites is a cause of false-positive scans. Among them, mediastinal uptake caused by thymic hyperplasia can be observed. The aim of the present study was to review a series of 573 patients with differentiated thyroid cancer treated with 131-I after surgery between 1992 and 2003 looking above all for those with mediastinal images resembling thymus. This evaluation is presented together with some hypotheses on the relationships between thymus and thyroid. Moreover, some considerations are made on the differential diagnosis between thymus and mediastinal tumour thyroid residues.
The effect of endogenously stimulated gastrin on serum insulin level was investigated in 7 normal subjects. Glycine by mouth was chosen as gastrin releaser. The glycine drink caused a significant rise of serum gastrin and insulin levels either in the fasting state or during glucose stimulation. However, serum insulin response of same magnitude occurred when stimulation of gastrin secretion was prevented to occur by infusing glycine into the duodenum. The results suggest that post-glycine rise in serum insulin was not mediated by endogenous gastrin release.
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