The diagnostic value of sialographic and scintigraphic investigations was compared in 169 patients. In this group were 75 inflammatory diseases and 49 benign and malignant tumours. Sialograms and scintigrams were examined by different physicians who had no knowledge of the clinical data of the patients. The scintigraphic diagnosis was considered correct if any abnormal finding was noted. The sialographic diagnosis was considered correct if the actual disease was diagnosed. In spite of the less stringent requirements for a correct scintigraphic diagnosis the sialographic technique was found to be superior. Radioactivity uptake curves over the salivary glands did not improve the scintigraphic diagnostic accuracy.
The inOuence of transcortin-binding capacity on corticosterone tissue uptake and degradation in the infant rat were studied. It was shown that the T 4-induced increase of plasma transcortin level did not alter the corticosterone half-life, but caused areduction oe the virtual volume oe distribution and, as a consequence, oe the hormone metabolie c1earance rate.From a comparison between in vivo and in vitro tissue uptake oe the steroid, it was concluded that plasma transcortin binding sites strongly compete with tissue binding sites. In addition, some oe the fmdings would suggest that the liver may not store transcortin, as a moleeule exhibiting the same characteristics as the plasma counterpart.Horm. Metab. Res.: 2: 292-297 (1970) K e y -W 0 r d s: PlaSmtl Transeortin -Corticosterone Half-Life, Distribution Volume and Metabolie Clearanee Rate -Corticosterone Tissue Binding.
Accumulation of 99mTc-diphosphonate was observed in 2 of 12 patients with liver metastases who had primary adenocarcinoma of the large bowel. The area of excessive radionuclide concentration corresponded well to the location of the hepatic metastases. The literature on this subject is reviewed and a possible mechanism of radionuclide accumulation is discussed.
We evaluated the efficacy of methylprednisolone (MP) and dexamethasone (OM) in a randomized, prospective trial in 15 patients with primary and/or metastatic brain tumors. MP was given to 7 patients as an IV bolus of 1 gm, and tapered off in the following 7 days. OM was given to 8 patients at the daily dosage of 16 mgs for 7 days, and the day of surgery, and tapered off in the following 7 days. After 7 and 14 days, only the patients treated with MP showed a significant reduction in peri tumoral brain edema volume measured by CT scan (P
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