The I/D polymorphism of the angiotensin converting enzyme (ACE) gene and C102T polymor phism of the serotonin receptor gene (5 HT2A) were studied in a group of long living individuals from north western Russia. No significant differences in allele frequencies of these genes were detected between long liv ing individuals and young people. At the same time, strongly pronounced differences in the 5 HT2A gene A1 and A2 alleles in populations of the northwestern region of the Russian Federation and the United States (0.397 (A1) and 0.603 (A2), and 0.615 (A1) and 0.385 (A2), respectively) were detected. These significant pop ulation differences deserve serious attention and a detailed analysis of polymorphism in other serotonin sys tem genes in different populations of Russian Federation.
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