The article presents the results of using a drug with a controlled long-term release of a substance in a bolus form, which was administered orally to lactating cows with a predisposition to the development of metabolic disorders - first of all, the development of ketosis. As a result of the work, it was determined that in the experimental group of animals there was an unreliable increase in the concentration of total protein in the blood serum, while it should be noted that the phenomenon of the % ratio of albumin and globulins was impaired in animals of both groups. Also, in the experimental group of cows, the concentration of urea increased by 22%, which indicates the activation of protein metabolism, the cholesterol level in cows of both experimental groups increased. An analysis of the changes in lipids showed that the cholesterol concentration in the control group of cows by the 30th day of the experiment became 15% higher, and in the experimental group of animals - 27.9% higher, while the intergroup difference between them was 12.7%. The levels of triglycerides in animals of both groups were approximately the same and did not have significant differences, although their concentration slightly increased. The data obtained may indicate that under the action of boluses with prolonged release of components, there is a faster activation of metabolic processes in the body of cows in the postpartum period.
The article considers a clinical case of uterine fibroids in an East European Shepherd dog. The owners complained of uncontrolled urination in the animal, which was aggravated over the past three months, as well as an increase in the abdomen, refusal of active physical exertion, shortness of breath when going up and down stairs, and decreased activity. Appetite and thirst are unchanged. The age of the dog is 8.5 years, sex is female, not neutered, sexual cycles are not regular, the last estrus is more than a year ago. Examination of the studied animal showed obesity, shortness of breath, capillary filling rate - 1 second. Palpation - the abdomen is soft, there is discomfort during palpation of the abdominal organs, an attempt to urinate. In the study of blood: RBC - 7.9 * 1012 / l; WBC - 9.21 * 109 / l; HCT - 57.2%; Hb - 198 g/l (hyperchromemia); eosinophilia - 9%, lymphocytopenia - 12%; biochemical study of blood serum: AST - 60 IU / l, ALT - 41 IU / l, total protein - 78 g / l, albumins - 38 g / l, alkaline phosphatase - 50 IU / l, total bilirubin - 1.7 μmol / l, concentrations of calcium, potassium, sodium, chlorine, phosphorus - at the upper limit of the reference values. Urinalysis - biochemical - no deviations, pH - 5.5, sediment microscopy - granular cylinders - single, mucus ++, erythrocytes: 0-2-3 in PM, leukocytes: 1-2-1 in PM, crystals - a small amount , calcium oxalates. Ovariohysterectomy revealed a massive formation on the uterus on the right, densely elastic consistency, grayish-whitish color on the cut. Histological examination (eosin-hematoxylin staining) determined that the formation is benign - leiomyoma.
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