The present clinical study confirms that PMNLs intensively accumulate in the regions of cerebral infarction. The present study revealed that this accumulation correlated with the severity of the brain tissue damage and poor neurological outcome.
In a double blind, randomized trial, the effects of aspirin (1, 5, and 15 mg/kg) were compared with the changes in platelet aggregation at 6 and 24 hours after dosage. It is found that there is a negative correlation between aspirin hydrolysis velocity in blood and capability of aspirin to decrease platelet aggregation with ADP and collagen in patients with atherosclerosis. Relationship between these parameters depends on aspirin dosage. The correlation was more marked for low doses of aspirin. It is suggested that the effect of aspirin in low dosage on platelet aggregation might be ineffective in many patients without control of aspirin hydrolysis velocity in blood.
We investigated around 100 patients for one-year and then registered the information about the possible etiology of the stroke, type of disease, treatment, localization of the clot, age, as well as gender distribution of stroke patients' population. This general overview of risk factors, ways of treatment, diagnostics, care and monitoring of the stroke patients in Armenia might serve as a cornerstone work for further highlighting of new avenues for stroke treatment.
Background and Purpose In this study we investigated whether cerebrospinal fluid in patients with brain infarction possesses an activity that contributes to the evolution of brain ischemia. As a test, the effect of cerebrospinal fluid on Ca
By means of Doppler spectral analysis it was shown that internal carotid artery stenosis has a dynamic component that determines the possibility of changes in the area of stenosis under various influences. It was found that the cold pressor test may increase the area of stenosis in some patients for up to three to five hours. In such cases reduction of blood flow volume in the common carotid artery and decrease of cerebral blood flow in the ipsilateral hemisphere of the stenosis are observed. Such a response was effectively removed by nifedipine. At the same time nifedipine itself is capable of changing the area of stenosis, either enlarging or reducing it. In the first case enhancement of brain blood supply is observed, and in the second case, its decrease. The data obtained disclose one of the reasons for the variability in therapeutic effects of vasodilators in patients with cerebrovascular disorders.
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