Background: Organophosphorus (OP) compounds are insecticides which are widely used in agriculture. Acute organophosphorus poisoning is an important cause of morbidity and mortality in developing countries like India. In a limited resourced country like India, we need cheap and easily measurable biomarkers for predicting prognosis.Objective was to estimate creatinine phosphokinase and serum lactate dehydrgenase as prognostic markers in acute organophosphorus poisoning.Methods: Total 94 cases of OP poisoning admitted to KIMS Hospital, Hubbali between January 1st 2017 to December 31th 2017 were studied. Detailed history, clinical examination and lab investigations like pseudo cholinesterase, serum LDH and serum CPK were carried out. Peradeniya OP poisoning scale was applied to all study subjects and the severity of OP poisoning was graded as mild, moderate, severe. Data obtained was analysed by different statistical methods.Results: OP poisoning is more common in adults of age group between 20 - 30 years, Incidence is was more in male patients, Mortality rate is 12.8%. Mean values of serum LDH, serum CPK were negatively correlated with pseudcholinesterase levels and it was statistically significant. Correlation between the severity of OP poisoning (based on Peradenyia score) and biochemical parameters like serum CPK, serum LDH, was statistically significant.Conclusions: The correlation between the severity of OP poisoning and biochemical parameters was statistically significant and they are usefull in predicting development of respiratory failure.
Background: Human immunodeficiency virus (HIV) infection is characterized by decrease in CD4 cell count and immunodeficiency, leading to opportunistic infections (OIs) and tumors. Objective of this study was to find out any association between thyroid function abnormality and CD4 count, duration of disease and ART drugs.Methods: Among 300 HIV/AIDS Persons attending ART centre, M.Y. Hospital, or attending general OPD, or admitted as in patients Dept. of Medicine, MGM Medical College and M.Y. Hospital, Indore, India.Results: Amongst 300 HIV patients,62 (20.66%) had thyroid dysfunction, most common being subclinical hypothyroidism (24/300, 8.0%) followed by sick euthyroid (17/300, 5.6%) and subclinical hyperthyroidism (13/300, 4.3%). Overt hypothyroidism was present in 5 of 300 (1.66%) patients and overt hyperthyroidism was present in 3 of 300 (1.0%) patients. 25 of 152 (16.44%) and 37 of 148 (25%) male and female HIV patients had thyroid function abnormality. Thyroid dysfunction was significantly more observed in old HIV patients (42/150, 28.0%) than in newly diagnosed HIV patient’s group (20/150, 13.33%).Conclusions: This prevalence being fairly high, it can be suggested that all retro positive patients, recently diagnosed and on treatment also may be subjected for routine thyroid function testing.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.