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ALICE is a general-purpose heavy-ion experiment designed to study the physics of strongly interacting matter and the quark–gluon plasma in nucleus–nucleus collisions at the LHC. It currently involves more than 900 physicists and senior engineers, from both the nuclear and high-energy physics sectors, from over 90 institutions in about 30 countries.The ALICE detector is designed to cope with the highest particle multiplicities above those anticipated for Pb–Pb collisions (dNch/dy up to 8000) and it will be operational at the start-up of the LHC. In addition to heavy systems, the ALICE Collaboration will study collisions of lower-mass ions, which are a means of varying the energy density, and protons (both pp and pA), which primarily provide reference data for the nucleus–nucleus collisions. In addition, the pp data will allow for a number of genuine pp physics studies.The detailed design of the different detector systems has been laid down in a number of Technical Design Reports issued between mid-1998 and the end of 2004. The experiment is currently under construction and will be ready for data taking with both proton and heavy-ion beams at the start-up of the LHC.Since the comprehensive information on detector and physics performance was last published in the ALICE Technical Proposal in 1996, the detector, as well as simulation, reconstruction and analysis software have undergone significant development. The Physics Performance Report (PPR) provides an updated and comprehensive summary of the performance of the various ALICE subsystems, including updates to the Technical Design Reports, as appropriate.The PPR is divided into two volumes. Volume I, published in 2004 (CERN/LHCC 2003-049, ALICE Collaboration 2004 J. Phys. G: Nucl. Part. Phys. 30 1517–1763), contains in four chapters a short theoretical overview and an extensive reference list concerning the physics topics of interest to ALICE, the experimental conditions at the LHC, a short summary and update of the subsystem designs, and a description of the offline framework and Monte Carlo event generators.The present volume, Volume II, contains the majority of the information relevant to the physics performance in proton–proton, proton–nucleus, and nucleus–nucleus collisions. Following an introductory overview, Chapter 5 describes the combined detector performance and the event reconstruction procedures, based on detailed simulations of the individual subsystems. Chapter 6 describes the analysis and physics reach for a representative sample of physics observables, from global event characteristics to hard processes.

Biopsy specimens were obtained from the bronchial or the nasal mucosa of three patients with grass pollen-induced bronchial asthma or rhinitis 48 h after positive bronchial or nasal provocation test with grass pollen extract. T cell clones (TCC), derived from these and control specimens, were then assessed for their phenotype, allergen-specificity, profile of cytokine secretion and ability to provide B cell help for IgE synthesis. Out of 50 and 61 CD4+ TCC derived from the bronchial mucosa of the two patient with atopic asthma 11 (22%) and 19 (31%), respectively, showed both proliferation and cytokine production in response to grass pollen allergens under major histocompatibility complex-restricted conditions. Of these 21 (70%) exhibited a clear-cut type 2 T helper (Th2) profile and induced IgE synthesis in autologous peripheral blood B cells in the presence of grass allergens. All the other 9 grass-specific clones showed a Th0 pattern of cytokine secretion, but only 1 provided moderate help for IgE synthesis. In contrast, the majority of TCC, derived under the same experimental conditions from the bronchial mucosa of two nonatopic patients with toluene diisocyanate-induced asthma, were CD8+ and most of them produced interferon-gamma or interferon-gamma and interleukin-5, but not interleukin-4, in response to nonspecific stimulation. Of 22 CD4+ TCC3 (14%) derived from the grass-stimulated mucosa of the patient with allergic rhinitis, but none of those derived from the unstimulated nostril of the same patient, exhibited proliferation and cytokine production in response to grass allergens. All had a clear-cut Th2 profile and provided help for IgE synthesis by autologous B cells. These data indicate that inhalation of the relevant allergen results in the activation of allergen-specific Th2 lymphocytes in the airway mucosa of patients with allergic respiratory disorders. These cells may play a central role in determining the nature of the inflammatory response in the airways of atopic patients.

Experimental analyses of moderate temperature nuclear gases produced in the violent collisions of 35 MeV/nucleon 64 Zn projectiles with 92 Mo and 197 Au target nuclei reveal a large degree of alpha particle clustering at low densities. For these gases, temperature and density dependent symmetry energy coefficients have been derived from isoscaling analyses of the yields of nuclei with A ≤ 4. At densities of 0.01 to 0.05 times the ground state density of symmetric nuclear matter, the temperature and density dependent symmetry energies range from 9.03 to 13.6 MeV. This is much larger than those obtained in mean field Calculations and reflects the clusterization of low density nuclear matter. He are expected to be small and they are ignored in the calculation. In the work reported in reference [1] these virial coefficients were then used to make predictions for a variety of properties of nuclear matter over a range of density, temperature and composition. The authors view this virial equation of state, derived from experimental observables, as modelindependent, and therefore a benchmark for all nuclear equations of state at low densities. Its importance in both nuclear physics and in the physics of the neutrino sphere in supernovae is discussed in the VEOS paper [1]. A particularly important feature of the VEOS, emphasized in reference [1], is the natural inclusion of clustering which leads to large symmetry energies at low baryon density.In this paper we extend our investigations of the nucleon and light cluster emission that occurs in near-Fermi energy heavy ion collisions [2,3,4,5,6] to investigate the properties of the low density participant matter produced in such collisions. The data provide experimental evidence for a large degree of alpha clustering in this low density matter, in agreement with theoretical predictions [1,7,8,9]. Temperature and density dependent symmetry free energies and symmetry energies have been determined at densities of 0.05ρ 0 or less, where ρ 0 is the ground state density of symmetric nuclear matter, by application of an isoscaling analysis [10,11]. The symmetry energy coefficient values obtained, 9.03 to 13.6 MeV, are much larger then those derived from effective interactions in mean field models. The values are in reasonable agreement with those calculated in the VEOS treatment of reference [1]. EXPERIMENTAL PROCEDURESThe reactions of 35A MeV 64 Zn projectiles with 92 Mo and 197 Au target nuclei were studied at the K-500 SuperConducting Cyclotron at Texas A&M University, using the 4π detector array NIMROD [3]. NIMROD consists of a 166 segment charged particle array set inside a neu-

SummaryA large number of CD4 + human T helper type 1 (Thl) clones specific for purified protein derivative and of Th2 clones specific for the excretory/secretory antigen of Toxocara canis, derived from the same individuals, were analyzed for both cytotoxic capacity and helper function for immunoglobulin (Ig) synthesis. The great majority of Thl, but only a minority of Th2 clones exhibited cytolytic activity. All Th2 (noncytolytic) clones induced IgM, IgG, IgA, and IgE synthesis by autologous B cells in the presence of the specific antigen, and the degree of response was proportional to the number of Th2 cells added to B cells. Under the same experimental conditions, Thl (cytolytic) clones provided helper function for IgM, IgG, and IgA, but not IgE, synthesis with a peak response at 1:1 T/B cell ratio. At higher T/B cell ratios, a strong decrease of Ig synthesis was observed. All Thl clones lysed Epstein-Barr virus transformed autologous B cells pulsed with the specific antigen. The decrease of Ig production at high T/B cell ratios correlated with the lytic activity of Thl clones against autologous antigen-presenting B cell targets. These data suggest that Thl differ from Th2 human T cell clones not only for their profile of cytokine secretion, but also for cytolytic potential and mode of help for B cell Ig synthesis.