Summary
Seven individuals from one family are recorded who have a syndrome consisting of hyperpigmentation, hypohidrosis and dystrophy of the nails. Associated features are punctate keratoses of the palms and soles, hypoplasia of the dermatoglyphics, atrophic changes of the skin of the face, bullae on the feet and dental anomalies. The disorder is inherited as an autosomal dominant trait. The relationship between this and other syndromes with hyperpigmentation is discussed.
A Porto-jet injector was employed to treat forty-five cases of granuloma annulare and five cases of necrobiosis lipoidica with triamcinolone acetonide or sterile normal saline. Complete clearance of granuloma annulare lesions was achieved in nearly 70% of those receiving triamcinolone and in 44% with saline. Inadequate penetration of lesions was responsible for a number of failures. The rate of recurrence after treatment was high but retreatment was usually successful. In three cases of necrobiosis lipoidica complete resolution occurred, while in one, partial improvement was obtained. No serious complications of this type of treatment were observed.
Summary
A patient is reported who had a connective tissue type of disease clinically similar to vinyl chloride disease. It is suggested that this may have been caused by abnormal sensitivity to perchlorethylene to which he was exposed in his occupation.
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