Mucoadhesive buccal patch releasing drug in the oral cavity at a predetermined rate may present distinct advantages over traditional dosage forms, such as tablets, gels and solutions. A buccal patch for systemic administration of acyclovir in the oral cavity was developed using polymers hydroxy propyl methyl cellulose (K4M), hydroxy propyl methyl cellulose (K15M), sodium carboxy methyl cellulose and poly vinyl pyrolidone (K30), plasticizer poly ethylene glycol (400) and a backing membrane of Eudragit (RL100). The films were evaluated in terms of swelling, residence time, mucoadhesion, release, and organoleptic properties. The optimized films showed lower release as compared to controlled drug delivery systems. Hence, an inclusion complex of acyclovir was prepared with hydrophilic polymer hydroxylpropyl beta-cyclodextrin in the molar ratio of 1:1. The inclusion complex was characterized by optical microscopy, FAB mass spectroscopy, and FTIR spectroscopy. Patches formulated with the acyclovir inclusion complex were evaluated along the same lines as those containing acyclovir alone. The in vitro release data revealed a substantial increase from 64.35% to 88.15% in the case of PS I and PS II batches, respectively, confirming the successful use of inclusion complexes for the formulation of buccal patch of acyclovir.
Methyl 12-and 18-vinyloxystearates were prepared by vinyl transetherscation with ethyl vinyl ether. Stannic chloride initiated cationic polymerisation of these monomers in cyclohexane yielded colourless viscous liquids having a degree of polymerisation of about 20. The ester groups in the polymers Were hydrolysed to give the corresponding polyacids and were reduced to give the corresponding polyols. ZUSAMMENFASSUNG: 12-und 18-Vinyloxystearinsauremethylester w d e n durch Umatherung mit Athylvinylather hergestellt und mit Zinnchlorid (SnCh) kationisch polymerisiert. Die polymeren Produkte waren farblose, viskose Fliissigkeiten mit einem Polymerisationsgad von etwa 20. Die Polymeren wurden entweder zu den entsprechenden Polysauren hydrolysiert oder zu den entsprechenden Polyalkoholen reduziert.
Homopolymerisation of vinyl stearate and its copolymerisation with five other fatty vinyl monomers have been carried out in benzene using benzoyl peroxide as the initiator. The comonomers included stearyl acrylate, stearyl methacrylate, allyl stearate, stearyl vinyl ether and divinyl sebacate. Stearyl acrylate and stearyl methacrylate furnished copolymers with inherent viscosities much higher than that of the vinyl stearate homopolymer while allyl stearate and stearyl vinyl ether gave copolymers with inherent viscosities much lower than that of the vinyl stearate homopolymer.
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