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Background: Dengue is the most rapidly spreading mosquito-borne viral disease in the world. A number of Dengue Haemorrhagic Fever (DHF) risk factors had been suggested. However, these risk factors may not be generalized to all populations and epidemics for screening and clinical management of patients at risk of developing DHF/ Dengue shock syndrome (DSS).Methods: A hospital based prospective case control study was done by taking 40 cases each of dengue fever with diabetes mellitus, hypertension, diabetes and hypertension and 30 cases of dengue with asthma/COPD and these patients were compared with controls of 100 patients with dengue fever but no comorbidities. All patients had Dengue serology NS1 or IgM positive.Results: Patients admitted with dengue fever with comorbidities had increased duration of hospitalization with P value of 0.012. The clinical outcome of the 250 patients. In the subgroup of dengue fever patients with DM and Dengue fever with DM and HTN, they were noted to have a 2.69 and 3.06 times increased risk effect of DHF.Conclusions: Dengue fever with DM or DM with HTN have a higher risk of developing DHF when compared with patients with dengue fever with no comorbidities. This finding helps us in triaging patients with comorbidities who develop dengue fever for specialized care and closer clinical monitoring.

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Background of Study: Incidence of diabetes is increasing due to increase in the prevalence of risk factors of this disease. Diabetes is also a risk factor for other diseases especially cardiovascular diseases. Increase in co-morbidities results in polypharmacy which in turn increases possibility of drug interactions. This study was conducted to evaluate the prevalence of possible drug interactions involving oral hypoglycaemic agents in Type II diabetes mellitus patients. Methods and Findings: This is a prospective, observational study, conducted for a period of 6 months, from September 2017 to February 2018. Type II diabetes mellitus patients with prescription of one or more oral hypoglycaemic drugs were included in the study. The demographics, and drug therapy related details of patients were recorded in the specially designed patient profile form. The drug interactions were assessed using Micromedex 2.0, Medscape and www.drugs.com. Results: A total of 136 interactions were reported in 63 patients. We detected 63 possible moderate interactions. Between oral hypoglycaemic agents. Interaction between Metformin and Salbutamol was most commonly seen interaction. Metformin and Glimepiride were the oral hypoglycaemic agents most commonly involved in drug interactions. Conclusion: Glimepiride and metformin were most commonly involved oral hypoglycaemic agents involved in drug interactions. Impairment of blood glucose control, increase in the risk of lactic acidosis, increase in the prevalence of hypoglycaemia, masking the effects of hypoglycaemia were the most common expected complications of these interactions. Therefore constant monitoring of the above symptoms is required while prescribing the mentioned combinations.

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