The effect of atomic heterogeneity on the exact probability distlibution of structure factors has been studied by regulating two factors p=NHINL and g=fH/ri (NJ-J,NL: number of heavy and light atoms in the asymmetric unit: fH,fL: atomic scattering factors for heavy and light atoms respectively). A number of real examples of various p and g values indicating different degrees of heterogeneity have been studied. We have defined a modified structure factor E' in cases of atomic heterogeneity and shown that E' is Gauss distributed irrespective of whether E is Gauss distributed or not. In general the curves of P(E) vs E show humps, oscillatory in nature, the oscillations being about the Gaussian fall of P(E') vs E' curve. Depending on the values of p and g the agreement between the two disttibutions vary from being poor to excellent. In cases where the agreement is excellent it should be possible in principle, to obtain the heavy atom position. Though it seems apparent that heterogeneity should increase with the increase of the number of heavy atoms present, it is a notew01thy observation that this is true upto a ce1tain value of p following which any increase in p decreases the heterogeneity. An explanation for this observation has been attempted.The correspondence for the above distribution with the tnmcated Cauchy distribution has been compared for different degrees of heterogeneity.
An attempt has been made to study the effect of atomic heterogeneity of various degrees on the probability distribution of the normalised structure factors. This treatment provides a method of studying separately the effect of two factors affecting heterogeneity, namely
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