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Five strains of a new alkalophilic bacterium have been isolated from potato-processing effluent. These strains are Gram-positive, non-sporing, motile rods which form an orange, cell-bound pigment and are capable of growth in aerobic or anaerobic conditions at a pH up to 11.5 and between 7 and 43 "C. For one representative strain the highest growth rate occurred in the pH range 8 to 10.5 and the minimum doubling time observed was 27 min at approximately 38 "C. With glucose as substrate, lactate, acetate and formate were major end-products, the proportions depending on cultural conditions.

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The design and synthesis of a series of 3H-benz[e]indol-8-amines are described. Two of the compounds are potent, orally active dopaminergic agents as established by their ability to induce contralateral turning in rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal pathway, to induce ambulation in rats rendered akinetic by bilateral injections of 6-hydroxydopamine into the anterolateral hypothalamus, and to antagonize reserpine-induced catalepsy in mice. The dopamine agonist activity of the 3H-benz[e]indol-8-amines establishes that a pyrrolo ring and a phenolic hydroxyl group can interact similarly with the dopamine receptor and provides evidence for the existence of a hydrogen-bond acceptor nucleus on the dopamine receptor macromolecule that is involved in the behavioral manifestations of dopamine agonists.

No abstract