In 9 patients with myeloproliferative diseases (MPD) (6 with myelofibrosis, MF, 1 with Ph1 positive chronic granulocytic leukaemia, CGL, 1 with primary eosinophilia, PE, 1 with pre‐leukaemia syndrome, preL) collagen, epinephrine, and ADP‐induced aggregation, N‐ethylmaleimide‐induced malondialdehyde (MDA) production, beta‐thromboglobulin (beta‐TG) plasma levels, and platelet turnover were studied. Collagen‐induced aggregation was found to be normal in 7 patients, absent in 1, and reduced in 1. In all but 3 patients, aggregation with ADP was markedly reduced. Epinephrine‐induced aggregation was decreased in 7 patients. No difference was found between mean MDA production in MPD (3.21 ± 0.50 nmol/109 PLTs) and in a control group of 21 normal subjects (3.04 ± 0.26 nmol/109 PLTs). Mean beta‐TG levels were significantly higher (P < 0.01) in MPD patients (165.00 ± 28.29 ng/ml) than in healthy controls (81.76 ± 14.63 ng/ml). Mean platelet production half‐time was significantly shorter in MPD (2.48 ± 0.24 d) than in the control group (3.43 ± 0.17 d), after adjustment for age by covariance analysis (P < 0.005). Our data do not indicate an abnormal prostaglandin synthesis and are consistent with the hypothesis that a disseminated intravascular platelet aggregation might take place in MPD patients.
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