The immunological and immunogenetic features of juvenile rheumatoid arthritis in the Kyrgyz population are studied for the first time. The study was conducted in 30 healthy children and 67 patients aged 3 to 16 years. The method of rosette formation was used. Associative links were established in the systemic form of juvenile rheumatoid arthritis with histocompatibility antigens in the HLA Cw5, B12 system, and the B15, A2, A9 antigens with high activity of the process, early development of bone and cartilage destruction and functional impairments. In the first 6 months of disease, it recommended the appointment of an aggressive baseline therapy.
The clinical features of articular syndrome and extra-articular manifestations in children with Reiter’s syndrome (illness) were studied. Reiter’s syndrome in childhood has some features of the course and development of the disease. In childhood, asymmetry of lesions of the joints of the lower extremities with early involvement of small feet joints in the process, possible flushing of the skin over the affected joints, intense pain, rare involvement in the process of the hip joints, lumbar spine and unilateral sacroiliitis is characteristic. Extraarticular manifestations proceeded often erased, and sometimes were not determined at all. Relapses and a chronic course are not excluded.
The article presents the results of treatment of 27 children with immune thrombocytopenic purpura in the process of high-altitude climate therapy. All children had approved final diagnosis and no positive hormone therapy (prednisone) effects. As a result of the ineffectiveness of drug therapy, patients were sent to the high-altitude climate therapy. In the process of high-altitude climate therapy, two children achieved complete and 17 children achieved partial remission. Improvement of clinical and hematological parameters was temporary in 6 children, and lack of effect was registered in 2 children. During the year of observation, no treatment was needed in children with complete, partial remission and clinical and hematological improvement.
The article presents the results of 92 preterm infants with various pathological conditions (study group) and 28 “conditionally healthy” preterm infants (control group). Bacteriological inoculation in premature infants was performed on the 1-7th day of life. To establish the features of the formation of intestinal microflora of a premature newborn in various pathological conditions in the early neonatal period.
The article presents the results of a hormonal examination of 69 children with acute skin allergic diseases, who received hospital treatment at the National Center for the Protection of Motherhood and Childhood. This made it possible to identify the features of hormonal shift in various manifestations of urgent skin allergic diseases in children. A link has been established between the clinical severity of the disease hormonal imbalance.
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