The current experiment was designed to investigate whether changes in prolactin concentrations might be involved in the seasonal change in responsiveness of the hypothalamic-pituitary axis to the negative feedback effects of oestradiol in the ewe. Twelve Dorset Horn ewes (long breeding season) and 12 Welsh Mountain ewes (short breeding season) were ovariectomized after insertion of empty subcutaneous implants (N = 2 per breed), or ones containing oestradiol-17 beta (N = 10 per breed). Intact ewes, 10 of each breed, were used to monitor breeding activity. Mean weekly plasma LH concentrations in oestrogen-treated ovariectomized ewes of both breeds were elevated over the period corresponding to their respective breeding seasons, but were basal during anoestrus. The changes in prolactin concentrations, however, followed the same temporal pattern in both breeds and were approximately parallel to changes in daylength. These data support the suggestion of a seasonal change in negative feedback responses to oestradiol which corresponds to changes in breeding activity, but any involvement of prolactin in this response remains questionable.
Carcass and eating quality characteristics of crossbred wether and female lambs sired by Charollais (C), Suffolk (S) and Texel (T) rams out of Mule ewes (Bluefaced Leicester ♂ × Scottish Blackface ♀ or Swaledale ♀J)were evaluated in a study carried out over a 3-year period in an upland flock. A total of 10 unrelated rams of each breed were used as sires. Lambs (no. = 280) were selected for slaughter at the same estimated subcutaneous fat level on four occasions within each year (i.e. at weaning in July and at approx. monthly intervals thereafter). Following slaughter, the left side of each carcass was physically dissected. A loin joint from lambs slaughtered in the 2nd and 3rd years of the study (no. = 184) was used to evaluate eating quality.Suffolk-sired lambs were heavier at slaughter (S: 42·2; C: 41·0; T: 40·7 (s.e. 0·35) kg) but had similar killing-out proportions compared with the other two breeds (S: 444; C: 450; T: 452 (s.e. 26) g/kg). Texel-sired lambs had higher lean proportion (S: 543; C: 550; T: 567 (s.e. 4·4) g/kg) and lower total carcass fat proportion (S: 240; C: 242; T: 233 (s.e. 5·3) g/kg) compared with S and C sired lambs. Bone proportion was similar for C and T lambs but was higher for S (S: 199; C: 191; T: 191 (s.e. 2·1) g/kg). Lean: bone (S: 2·75; C: 2·90; T: 2·99 (s.e. 0·037)) and lean:fat (S: 2·38; C: 2·40; T: 2·54 (s.e. 0·034)) ratios were higher for T-sired lambs. Female lambs were lighter (40·4 v. 42·2 (s.e. 0·24) kg), and had proportionately more intermuscular fat than wethers (122 v.118 (s.e. 1·3) g/kg) but the sex differences for other tissue proportions were small. Carcass weights and total carcass fat proportions increased and lean proportions decreased across the four slaughter dates. There were no effects of breed or sex on eating quality. However, samples from lambs slaughtered at weaning were judged to be more tender than those slaughtered later in the season.
Two groups of 6 rams were maintained under constant photoperiodic conditions consisting of short days (8 h light: 16 h dark; Group S) and long days (16 h light; 8 h dark; Group L) from 4 to 20 months of age. Five other rams were reared under a photoperiod representative of that occurring naturally (Group N). Testis size, plasma testosterone and prolactin concentrations were monitored weekly and sexual behaviour tests were carried out at regular intervals. Over the treatment period Groups S and L did not differ in terms of testis growth or plasma testosterone. Both groups had a phase of testis growth and increased testosterone followed by a decline and the temporal patterns for the two groups were equivalent. Sexual behaviour was slower to develop in Group L than in Group S, indicating that photoperiod can affect the development of sexual behaviour irrespective of peripheral plasma testosterone concentrations. Plasma prolactin levels showed a cyclic variation in Group L and were significantly higher overall than in Group S rams. This, together with a trend towards negative correlations between prolactin concentrations and sexual behaviour in Group L, indicates that prolactin may be involved in the effect of photoperiod on sexual behaviour. The presence of a cycle of testicular growth and of hormone concentrations in young animals under constant photoperiod tentatively suggests that these cycles are endogenous. The constant photoperiod did, however, affect the animals because the cycles which occurred in Groups S and L were out of phase with those of Group N by about 4 months.
Disodium pamidronate (APD) is a potent inhibitor of bone resorption, with less risk of defective mineralization than earlier bisphosphonates. We assessed the response to six spaced low-dose intravenous infusions of APD given at intervals of approximately 6 weeks followed by weekly infusions if bone turnover remained abnormal. Three groups of 10 patients were studied, each group receiving infusions of 15, 30, or 45 mg. Hydroxyproline excretion fell by 62% and alkaline phosphatase was reduced by 72%, with no difference between the dose levels. A total of 21 patients (70%) achieved normal levels of bone turnover, indicating that low-dose infusions of APD are a safe and effective treatment for Paget's disease.
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