No abstract

Background: Isotretinoin suppresses sebum development by inducing sebocyte apoptosis, which is induced by the expression of tumour necrosis factor-related apoptosis-inducing ligand, insulin-like growth factor binding protein-3, and neutrophil gelatinase-associated lipocalin, which is induced by isotretinoin. While apoptosis could play a role in the drug's key mechanism of action, it may also be to blame for the majority of isotretinoin's side effects, including ovarian reserve impairment. The aim of this study was to see if AMH could be used as a measure of ovarian reserve in isotretinoin-treated acne patients. The participants in this study were 66 female patients in their reproductive years who had various degrees of acne. All of the patients were chosen from the Dermatology and Andrology Department of Benha University Hospitals' outpatient clinic. The research lasted anywhere from 6 to 12 months. The average age of the patients in this study was 25 years, with a standard deviation of 6 years. There was no substantial difference in AMH before and after Isotretinoin therapy. The percentage change in AMH after treatment had no important relationship with the patients' age, Isotretinoin dosage, or treatment period. Isotretinoin has a negative impact on the ovaries, according to the findings. More research is required to gain a better understanding of this subject and to see if the effects are permanent.

Background: Considering the recognized roles of ICAM-1 in inflammation and rising an evidence that inflammation is evident at all stages of AV. The current study aimed to investigate the incidence of ICAM-1 gene expression and polymorphism with special reference to amino acids at position 469 and 241 with acne vulgaris and its possible correlation with the lesion severity. Patient and methods: The present case control study included 60 participants of matched age, sex and of Egyptian origin where there were 45 acne patients assigned into three groups according to acne severity (mild, moderate and severe), 15 patients in each group, and there were 15 participants as control.All studied participants were tested for the genotypes of ICAM-1 gene polymorphism by PCR where four primers have been used to detect all possible polymorphism at codon 241 and 469 Results: There was statistically significant difference among four studied groups as regard ICAM ( 496) and ICAM (241) polymorphism where the highest percentage of GG were among severe acne group and none of controls had GG genotype. There was significant association between ICAM (496) polymorphism and patients' BMI where the highest BMI Conclusion: ICAM-1 496 and 241 polymorphism might be associated with AV. Further understanding of functional significance of the ICAM-1 polymorphism will help delineate immunopathogenesis in certain subgroups of AV obese patients

Background:The gap between puberty and marriage is widening. Among Egyptian women aged 35 years and older, 3.3% have never-married. Objective: The current study was carried out to assess the type and frequency of nonpenetrative sexual activity among a sample of never-married Egyptian women. Patients and Methods: A total of 300 never-married women, aged 18-39 years, were the participant of this study. Their sexual activity and related matters were surveyed using a self-report questionnaire designed by the authors. Results: Overall, 45% of women described their degree of arousal as 'somewhat difficult.' Romance novels were the most common cause of sexual arousal (58%). After arousal, only 18.7% reported that they release their sexual tensions by masturbation. Guilt feelings were the cause that prevented 80% of women from masturbation. Indulging in a romantic relation was admitted by 27% of the sample. This relation most commonly was in the form of speaking on the phone or chatting on WhatsApp with a male partner. Admission to the presence of a romantic relation was more common in rural living women. Conclusion: Sexual arousal was most commonly caused by romantic novels in our sample. After arousal, masturbation may be the method of releasing tension, as physical contact with members of the opposite sex seems to be rare.