A new laboratory method for isolating the glycosides stevioside and rebaudiosides A and C from leaves of Stevia rebaudiana was proposed. According to HPLC, the glycoside contents in plants grown in Russia (Voronezh Oblast') and Ukraine (Crimea) were 5-6% (stevioside) and 0.3-1.3% (rebaudiosides A and C).

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Diesters based on isosteviol and dicarboxylic acids were synthesized and tested for antituberculous activity. Isosteviol and some of its derivatives exhibit appreciable tuberculostatic properties in vitro, the activity being dependent on the length of the polymethylene spacer connecting two ent-beyeran fragments.The mechanism of the antituberculous action of isosteviol derivatives are discussed. 473 0091-150X/06/4009-0473

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