INTRODUCCIÓNDesde 1983 en que el Helicobacter pylori (H. pylori) fue aislado con éxito (1), ha sido el bacilo más estudiado en el mundo, revolucionando el enfoque clínico y fisiopatológico de las enfermedades gastroduodenales (2). Se ha encontrado el H. pylori en el 70 a 80% de los casos de gastritis y hasta en el 100% de los casos de úlcera péptica (eliminando los casos por antiinflamatorios no esteroideos y Zollinger-Ellison) (3). Seropositividad a ABSTRACTObjective: to associate serologic response to Helicobacter pylori (Hp) among seropositive university students and their families in western Mexico.Methods: we conducted a comparative transversal study, and randomized 30 nuclear families of 14 Hp-seropositive university students and 14 Hp-seronegative university students. We carried out seropositivity measurements (IgG) to Hp using the ELISA method. An analysis was performed utilizing the chi-squared and Mann-Whitney U tests, with the aid of EPI INFO 2000 and SIG-MA STAT 3.2 software.Results: global seropositivity in the families of infected students was 57 vs. 13% of the relatives of non-infected students (p = 0.000002). In families of Hp-positive students we found the following frequencies: parental (father and mother) 70%; mother 71%, and siblings 42%, while for seronegative individuals incidences were: parental 17% (p = 0.00005), mother 12% (p = 0.001), and siblings 10% (p = 0.0076).Conclusions: there is a greater prevalence of antibodies against Hp in the relatives of seropositive students.
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