BackgroundChondroid syringomas (CS) are rare benign mixed tumours. Clinical differentiation can be misleading due to the silent presentation, with only histopathological findings confirming the diagnosis.Case reportA 23-year-old Caucasian gentleman presented with an eighteen month history of increasing size of his exophytic upper lip mass.The initial clinical impression was thought to be related to the skin. Following a punch biopsy, histopathology confirmed appearance in keeping with part of a chondroid syringoma with subsequent excision of the lesion.DiscussionCS present as a slow-growing, asymptomatic, non-tender, nonulcerated, smooth, firm subcutaneous, or intradermal nodule and can range from 0.5 to 3.0 cm, predominantly occurring in the head and neck region in patients aged above 35 years with a male predication. The most effective diagnostic method is microscopic examination. The gold standard treatment modality is by complete excision with a margin of normal tissue in order to examine the histopathologic features and prevent recurrence.ConclusionCS should be included as a differential diagnosis of facial subcutaneous skin lesions in middle aged male patients. Careful evaluation, with a view of total excision and adequate surgical margin will enable diagnostic confirmation, whilst maintaining the aesthetic and functional unit.
Background: Epidermal growth factor (EGF) promotes tumourigenesis and tissue repair of epithelial and mesenchymal cells, and may therefore have a role in initiating or promoting oral carcinogenesis.Objectives: We aim to study the clinicopathologic and prognostic significance of preoperative serum level of EGF in patients with oral squamous cell carcinoma. Methods: We retrospectively analysed 152 patients underwent surgery whose preoperative serum EGF level was determined by an enzyme-linked immunosorbent assay and 44 age-and sexmatched controls. Findings: Patients with higher serum levels of EGF were more likely to have neck lymph node metastasis (P = 0.013), worse survival (P = 0.014), a tendency for more advanced stage cancer (P = 0.07), and poorer cancer-specific survival (P = 0.011). After tumour ablation surgery, the serum level of EGF decreased in 81% of patients (36/44). Multivariate analysis using the Cox proportional hazards model indicated that EGF level was an independent predictor of poor survival (HR = 1.07; 95% CI = 1.01-1.03; P = 0.027).
Conclusion:In patients with oral squamous cell carcinoma, higher preoperative serum level of EGF was associated with neck lymph node metastasis, more advanced stage, and poor survival. EGF should be considered as a potential prognostic biomarker and a therapeutic target for patients with this cancer.
Exposure of the torus palatinus during reduction surgery often presents with some difficulties, namely, achieving adequate exposure while minimising trauma to the palatal mucosa. In this article, we describe a simple technique that provides generous access, and further reduces trauma, to the palatal mucosa.
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