Dermorphin-related peptides from the skin of Phyllomedusa bicolor and their amidated analogs activate two ,u opioid receptor subtypes that modulate antinociception and catalepsy in the rat ([Lys7]
ABSTRACTThree naturally occurring dermorphin-like peptides from the skin of the frog PhyUomedusa bicolor, the related carboxyl-terminal amides, and some substituted analogs were synthesized, their binding profiles to opioid receptors were determined, and their biological activities were studied in isolated organ preparations and intact animals. The opioid binding profile revealed a very high selectivity of these peptides for IA
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