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followed by rearrangement of the [4.4] to the [3.5] bicycles.9 (9) Cf. calathene ("basketene") to rhynchene ("snoutene"): W.

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A CONTINUING EFFORT is being made in these laboratories to synthesize potential medicinal agents. A recent review article (7) discusses some 5-ary l-6-alkyl-2, 4-diaminopyrimidines. Hitchings and Russell (3) have published an apparently general route for the preparation. In this method «-acylphenylacetonitriles are converted by reaction with diazomethane (3), or by reflux with isobutyl alcohol and p-toluenesulfonic acid to their enol ethers (4), and then condensed with guanidine to give the 5-phenyl-6alkyl-2,4-diaminopyrimidines in good yield. The present article describes the extension of this procedure to the synthesis of 5-aryl-6-arylmethyl-2,4-diaminopyrimidines containing Cl, F, and CF:i groups in the aryl rings with emphasis on the fluorine derivatives because of current

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