Traditionally, the leaves of Clematis wightiana have been used in the treatment of rheumatism, indigestion, headaches, varicose veins, bone problems, nasal congestion and sinus. The present study was conducted to evaluate the
phytochemical profile, quantification of secondary metabolites and free radical scavenging capacity of C. wightiana leaf.
The total phenolic, tannin and flavanoid content of C. wightiana leaves were quantified and were found to be higher in the
ethyl acetate extract. Subsequently, the extracts were subjected to appraise their antioxidant capacity by availing various
in vitro antioxidant assays namely DPPH radical scavenging assay, ABTS assay, Phosphomolybedenum assay, Ferric
Reducing assay, Superoxide Radical Scavenging assay and Reducing power assay. The results of the antioxidant assays
revealed that the ethyl acetate extract of C. wightiana leaves possess better free radical scavenging activity than other
solvent extracts. Thus, the finding of the study elucidates the perception on phytochemical and bioactivity of C. wightiana
which could be used in development of phytotherapeutics to enchance human health.
Keywords: Clematis wightiana, Antioxidant, Superoxide radical scavenging, In vitro antioxidant assay, DPPH,
Ethnomedicine.
Author summary
We report a case of rabies encephalitis in a 4½-year-old male child with an exposure to a suspect rabid dog. The child developed rabies 25 days after receiving postexposure prophylaxis. Rabies immunoglobulin (RIG) is currently administered according to body weight. In high-risk exposures over the head and neck, local administration of RIG over and above the body weight depending on the site, size, and severity of exposure may help to prevent rabies death. There is a need for further studies to generate new evidence in this regard.
Background: HIV infection in India is a major public health problem. The anti-retroviral therapy (ART) centre is the backbone of the national acquired immune deficiency syndrome (AIDS) control program (NACO). To assess the trend of new people living with human immunodeficiency virus (PLHIV) registered at an ART centre in Bangalore and their treatment status.Methods: All the PLHIV registered at an ART centre from 1st January, 2009 to 31st December, 2018 were included in the study. PLHIV registered but not initiated on treatment, were excluded.Results: Out of 4428 PLHIV registered at an ART centre, 2964 were initiated on treatment. The youngest PLHIV registered was 6 years, oldest was 79 years and the decadal median age was 38 years. Majority (41.4%) were in the age group of 31 to 40 years. Predominant gender was male. A declining trend of new PLHIV, LFU/stopped/missed cases over the past decade was observed. The 1658 are alive, 402 died, 305 cases either missed, stopped or lost to follow up, 32 cases were opted out of the treatment and 567 cases were transferred out.Conclusions: A decline in number of new PLHIV, LFU, missed and stopped over the decade was observed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.