The paper illustrates some improvements in the seismic risk assessments in Italy and describes the differences deriving from the use of different approaches to calculate the losses and the influence exerted by different hazard results. The first method of risk evaluation, here termed as 'direct', evaluates the losses by using only the mean values of the main variables involved (rate of events and frequency of the damage levels), thus providing an approximation of the expected losses. The second method, named 'probabilistic', takes into account the uncertainties related to the number of events (hazard) and the damage levels (vulnerability), thus determine the probability associated to each level of loss. Both methods express the risk as the economic losses to dwellings within a reference period of time. Two alternative hazard results are also used to show the influence on the calculated risk: the first one considering the seismicity uniformly distributed within seismic source zones; the second one clustering the strong seismicity in geographically narrowed source zones and scattering the low seismicity over large source zones.The results obtained show that the losses estimated by the 'direct' method are, at national level, a little bit lower than those obtained with the probabilistic method (about 6%). The differences are more pronounced at local level (regional or sub-regional), generally within ±20% with larger values in the zones of lower risk. Nevertheless, also the two hazard results show more pronounced differences at local rather than at national scale. The risk estimates in the high seismicity areas are greater if using the seismic hazard results based on the clustered seismicity, but the reverse is true, in the low seismicity areas, if using the hazard results based on the uniformly distributed seismicity.As a concluding remark, the direct method for calculating losses and the implementation of any seismic hazard result, may be acceptable for a general picture of the risk; whereas, when a detailed description of the territorial distribution of risk is needed, the probabilistic method for computing losses and a well-focused seismic hazard method should be used, as they are more pertinent to describe and highlight local differences.Abbreviations: GdL96 -hazard and risk results from the 'Working Group, 1996'; SCS -hazard and risk results from the 'Spatially Clustered Seismicity' model; SSN -seismic and risk results from the 'National Seismic Survey'.

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Shortly after the October 31, 2002, Molise, Italy, earthquake, a widespread fitness-for-service and building damage assessment was launched. In two months, more than 23,000 buildings were inspected using a standardized damage assessment form. As many as 100 inspection teams, consisting of public servants and volunteer professionals, totaled approximately 80,000 person-hours. Analysis of the collected building type and damage data shows high-vulnerability masonry buildings with significant preexisting damage. With the sole exception of San Giuliano, the modal values of the observed damage occurred for the negligible-to-slight damage levels D=0 or D=1, with only a few buildings showing higher damage levels. Nevertheless, due to their high vulnerability, about 40% of the inspected buildings were unusable, with important consequences for the number of people needing shelter. The survey made it possible to determine the usability of about 12,000 buildings and the repairs needed for about 1,000 buildings.

Vasoconstriction in subjects with essential hypertension may therefore depend on a different regulation of ionic flow that probably supports an increased Ca2+ inflow in smooth muscle fibre cells. Under certain pathological conditions, some immune system components (i.e. interleukins, adhesion molecules) may directly enhance membrane permeability to Ca2+, thus inducing vasoconstriction in the smooth muscle cells.

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Serial electrocardiograms (ECGs) were studied prospectively in 80 apparently healthy newborn infants; 30 infants exposed in utero to prolonged tocolytic therapy (21 to ritodrine and 9 to isoxsuprine) and 50 infants non-exposed in utero to drugs (control group) matched for gestational age, Apgar score, and birth weight. Duration of exposure to tocolysis was at least 30 days (30-180 days) with an oral dosage of 10 mg 3 times daily. ECGs were graded for changes suggestive of ischaemia using the arbitrary grading system described by Jedeikin et al. In all infants with ECG features of myocardial ischaemia, serum creatine-phosphokinase iso-enzyme (CK-MB) activity was measured. Six out of 21 infants to ritodrine and six out of nine infants exposed to isoxsuprine showed a degree of ECG ischaemia which persisted for several weeks. No control infant presented grade 2 or 3 ECG changes after the 5th day of life. The results of this study seem to show that prolonged tocolytic therapy with beta-sympathomimetics has side-effects on the fetal myocardium and suggest that this treatment be reserved only for selective cases and/or for short periods of time.

In 1998, a new system of seismic classification promoted by the Department of Civil Protection identified the area in Italy hit by the 2002 earthquake in Molise and Puglia as a Zone 2 (moderately seismic). However, this classification was not adopted until March 2003, when an ordinance passed that partially closed the gap between scientific knowledge and official recognition of seismic hazard and that established a method for constantly updating the classification in the future. This paper reviews some of the methods available to assess the seismic hazard, particularly referring to the rich seismic history of Italy and using the “Associated Seismic Area” concept. This study confirms that the area affected by this earthquake should be considered as Zone 2. An appendix presents data on the seismic risk of existing buildings in the area and concludes that it is high for masonry buildings and that a strengthening program is needed.

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