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In preschool-age children with moderate-to-severe virus-induced wheezing, preemptive treatment with high-dose fluticasone as compared with placebo reduced the use of rescue oral corticosteroids. Treatment with fluticasone was associated with a smaller gain in height and weight. Given the potential for overuse, this preventive approach should not be adopted in clinical practice until long-term adverse effects are clarified. (ClinicalTrials.gov number, NCT00238927.)

Abstract-We investigate central issues such as invertibility, stability, synchronization, and frequency characteristics for nonlinear wavelet transforms built using the lifting framework. The nonlinearity comes from adaptively choosing between a class of linear predictors within the lifting framework. We also describe how earlier families of nonlinear filter banks can be extended through the use of prediction functions operating on a causal neighborhood of pixels. Preliminary compression results for model and real-world images demonstrate the promise of our techniques.