Problems connected with the proposal to supplement alcoholic beverages and saccharine aerated water (" soft drinks ") with choline or its precursors are mentioned. Our findings are, of course, not necessarily applicable to alcoholism in human subjects. If they should prove to be so, it is increasingly obvious that individuals who habitually consume large amounts of alcohol or sugar lack adequate amounts of the lipotropic agents as well as of other dietary essentials. The classical hepatic lesions (fatty changes and fibrosis) associated with alcoholism in human subjects, the first descriptions of which are rfientioned in our introduction, may prove to be due specifically to a lack of the lipotropic agents. This work has been supported by the Nutrition Foundation of New York and the Banting Research Foundation, Toronto. We are indebted to our colleague Dr. Jean Patterson for her invaluable help. The photomicrographs were prepared by one of the authors (W.S.H.) with the technical assistance of Mrs. K. M. Robertson.

" AMELLIN" FOR DIABElES MEDICAL JOURNAL showed comparable variations, and it was obvious that amellin had not made the slightest difference to the closely studied pattern of his progress. This lest was undertaken on the suggestion of Dr. R. D. Lawrence and Prof. F. G. Young at the request of the Medical Research Council and the (then) India Office. Acknowledgment is due to Prof. M. C. Nath for his kindness in supplying a sample of amellin for the test.

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