OBJECTIVES Prognosis for patients with non-small-cell lung cancer (NSCLC) who, after neoadjuvant/induction and surgery, have a pathological complete response (pCR) is expected to be improved. However, the place of the pCR patients in the context of the tumour, lymph node and metastasis (TNM) staging system is still not defined. The aim of this study is to investigate the long-term survival of NSCLC patients with pCR and to find their appropriate staging category within the TNM staging system. METHODS We retrospectively reviewed the prospectively recorded data of 1076 patients undergoing surgery (segmentectomy or more) for NSCLC between 1996 and 2016. Patients were divided into 2 groups. Group 1: clinical early-stage patients who underwent direct surgical resection (n = 660); group 2: patients who received neoadjuvant/induction treatment before surgical resection for locally advanced NSCLC (n = 416). Morbidity, mortality, survival rates and prognostic factors were analysed and compared. RESULTS Postoperative histopathological evaluation revealed pCR in 72 (17%) patients in group 2. Overall 5-year survival was 58.7% (group 1 = 62.3%, group 2 = 52.8%, P = 0.001). Of note, 5-year survival was 72.2% for pCRs. In addition, 5-year survival for stage 1a disease was 82.6% in group 1 and 63.2% in group 2 (P = 0.008); 70.3% in group 1 and 60.5% in group 2 for stage 1b (P = 0.08). Patients with stage II had a 5-year survival of 53.9% in group 1 and 51.1% in group 2 (P = 0.36). CONCLUSIONS This study shows that patients with locally advanced NSCLC developing a pCR after neoadjuvant/induction treatment have the best long-term survival and survival similar that of to stage Ib patients.

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The purpose of this study is to examine the contribution of sport to obese youth duringsocialization, considering the socio-cultural and economic characteristics of obese adolescents. In the study participated 118 obese children members of Ankara Metropolitan Municipality Family Life and Youth Centers who played sports or participated in sport activities in the 15-18 age range. As a data collection tool, the socialization scale consisting of 69 questions developed by Sahan (2007) was used. A computer-aided data analysis program was used in the research data. Frequency analysis was applied first and tables were made during the analysis of the data. The percentages of the variables in the sample were determined, and the characteristics of the sample were evaluated generally in these tables. Analysis procedures were applied according to hypotheses later. The data were evaluated by the Scheffe test, the Mann Whitney U test and the Kruskal-Wallis Nonparametric test. As a result of the research; it was found that there was no significant difference between the levels of socialization of obese youth according to the age variable and there was a significant difference between sexes, household income levels and the sports and socialization levels of obese youth who are interested and who are uninterested in sport. At the end of the research, it was observed that male obese teenagers had higher levels of socialization than female obese teenagers in terms of high income level and interest in sport.

resection of right or left S6 was 88% in ISPG and 88% in ASCG. RR FEV1 in the segmental resection of S6 was 93% in ISPG and 91% in ASCG. The significant difference was shown in RR VC of the segmental resection of right S2 (p¼0.04). Conclusion: We consider the isolation along intersegmental plane exactly is superior to the method with automatic suture instruments from the viewpoint of respiratory function preservation while the difference may depend on the resected segment. We guess it is expected that the difference of the respiratory function preservation effect between the two groups grows big as much as the intersegmental plane is large.

GirişAkciğer kanseri tüm dünyada olduğu gibi yurdumuzda da en sık görülen kanser çeşidi olup vakaların %90'ında etiyolojide sigara bulunmaktadır. Sigara tüm akciğer kanser alt tiplerinde etiyolojide yer almakla birlikte en güçlü ilişki küçük hücreli ve skuamöz hücreli akciğer kanserlerinde izlenmektedir (1). Yalnız akciğer kanserlerine spesifik olarak kabul edilebilecek herhangi bir belirti bulunmamakta birlikte hastaların çoğunda öksürük, balgam, hemoptizi ve nefes darlığı görülmektedir. Diğer taraftan halsizlik, iştahsızlık ve kilo kaybı gibi sistemik belirtiler de görülebilmektedir (2). Alt tiplere göre değişkenlik göstermekle birlikte akciğer kanserleri özellikle tanıda gecikilen vakalarda sıklıkla metastatiktir. Bu bağlamda hastalarda metastazlara bağlı belirtilerle de karşılaşılabilmektedir. Lokal metastazlar dışında kemik, karaciğer ve beyin en sık metastaz yaptıkları organlardır (3).

Background: Two-dimensional CT measurement considered unreliable in the evaluation of small pulmonary nodule less than 2 cm, and a nodule less than 1 cm in diameter considered non-measurable according to RECIST criteria. The aim of this study was to determine the accuracy of visual assessment on the growth of immeasurable small pulmonary nodules less than 1 cm in diameter on CT. Methods: We selected 125 CT images (1-mm slice thickness axial images, lung window setting, lung algorithm) which have a small pulmonary nodule less than 1cm. Then, we magnified the pulmonary nodules to 120% in diameter using the Photoshop. We coupled these images to 125 sets of ingrowth and growth groups, respectively. Four radiologists with varying experience read these sets to five-point scale using visual assessment (definitely ingrowth, probably ingrowth, possibly growth, probably growth, and definitely growth). Results: The areas under the receiver-operator characteristic curves of visual assessment on growth of small pulmonary nodules were 0.975 for observer 1, 0.986 for observer 2, 0.989 for observer 3, and 0.913 for observer 4, respectively. Sensitivities were 96.0% (120/125), 98.4% (123/125), 98.4% (123/125), and 88.0% (110/ 125), respectively. Specificities were 99.2% (124/125), 99.2% (123/125), 98.4% (124/125), and 96.8% (121/ 125), respectively. Conclusion: Visual assessment showed high diagnostic performance for determining growth of non-measurable target pulmonary nodules with 20% increase in diameter.

Background: Curative intent treatment of stage III NSCLC may include surgery, radiotherapy, chemotherapy, or combination therapy. Management is influenced by both patient and disease characteristics. N2 disease is optimally treated with concurrent chemoradiotherapy (CRT) and the role of surgery after CRT remains a subject of debate. The recent PACIFIC study of adjuvant durvalumab after CRT in stage III showed unprecedented improvements in relapse free survival, which further calls into question the role of surgery. We sought to perform a real-world analysis of curative therapies in stage III NSCLC, and explore the impact of known prognostic factors on outcome. Method: A retrospective review was completed of all patients referred to BC Cancer from 2005-2012 with stage III NSCLC treated with curative intent including surgery, radiotherapy, chemoradiotherapy, and combined surgery and radiation +/-chemotherapy (S+RT+/-C). Information was collected on known prognostic factors. The primary outcome measure was overall survival. Result: 688 patients were included in the study. Baseline characteristics: female 47%, median age 65, ECOG 0-1 65%, weight loss <5% 74%, stage IIIA/ IIIB 73%/27%. Treatment: 82 (12%) surgery, 127 (18%) radiotherapy, 423 (62%) chemoradiotherapy, and 56 (8%) combined S+RT+/-C. Median overall survival: surgery 28.6m, chemoradiotherapy 27.6m, radiotherapy alone 18.0m, and S+RT+/-C 55.9m. In a multivariate model incorporating age, sex, weight loss, ECOG, and stage, the survival difference disappeared between the surgery, chemoradiotherapy, and radiotherapy cohorts and persisted in the S+RT+/-C cohort. Conclusion: In stage III NSCLC, the performance of surgery, chemoradiotherapy and radiotherapy alone are comparable after controlling for known prognostic factors. Combined S+RT+/-C appears to provide a significant benefit above other modalities in highly selected patients. The role of surgery post-CRT remains controversial, as immunotherapy demonstrates greater promise for improving outcomes for the diverse group of stage III NSCLC.

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