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We present the case of 35 years old female patient who came to our Institute with an unspecified abdominal pain,\ud hepatosplenomegaly and a previous alleged diagnosis of Budd-Chiari syndrome. Magnetic resonance imaging (MRI)\ud was crucial to identify a diffuse and infiltrating mass involving the liver in a misleading diagnosis. A discussion about\ud the imaging findings and differential diagnosis of a rare case of diffuse epithelioid hemangioendothelioma (EHE) is\ud provided as follows. MRI was the most important instrument to guide the diagnostic and therapeutic path, helping to\ud define the typical signal intensity of EHE, mainly with a hepatobiliary contrast agent. The differentiating between\ud other primary tumors, however, remains a complicated issue. Our purpose was to highlight the radiologic and MR\ud characteristics of this rare tumor in order to evaluate the diffuse EHE in the diagnostic proce