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7887protective groups (CBZ, formyl, and acetyl), including the easily removable ones; and (iii) various amino acid derivatives including both L-and D-isomers and dipeptides were utilized as nucleophiles.In summary, a radically altered stereospecificity of subtilisin in organic solvents affords facile enzymatic preparation, impossible in water, of diverse peptides containing D-amino acids, thus providing a new synthetic route to bioactive peptides. Scheme I' 1 2 3

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