A tandem one-pot solvent free approach for the direct conversion of benzyl alcohols to α-amino phosphonates and dihydropyrimidones is reported. The method relies on a metal free photo-oxidation of benzyl alcohols to benzaldehydes under UV irradiation using ammonium perchlorate followed by Kabachnik-Fields and Biginelli reactions. The reaction conditions are moderate and metal free with good substrate scope. The control experiments were performed to investigate the role of the ammonium perchlorate and molecular oxygen as oxidants. The quenching experiments in the presence of TEMPO and other radical quenchers suggest radical based mechanism.

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Nanotechnology as an emerging scientific field has enabled humanity to manipulate the environment at molecular and atomic level and has touched and even revolutionized all scientific fields due to its characteristic features. Medicine is one of the important fields that witnessed a nanotechnological revolution that guided medical scientists to device new approaches to study pathologies and explore genuine therapeutic tricks by exploring nanotechnology to operate on more specific molecular targets and to reduce the adverse risks and side effects imposed by the conventional approaches. By manipulating drugs and other materials, the fundamental properties and bioactivity of the materials can be altered at the nano scale. These tools can led to the different characteristics of drugs or agents such as a) modulation in solubility and blood pool retention time, b) controlled release over short or long durations, c) environmentally triggered controlled release or highly specific site-targeted deliver.