Novel tricyclic 1,4‐diazepine derivatives – pyrido[3′,2′:4,5]thieno[3,2‐e][1,4]diazepin‐2‐ones – have been synthesized. Azetidin‐2‐one moiety has been incorporated into the 1,4‐diazepine scaffold by [2 + 2]cycloaddition of functionalized ketenes to imine C═N bond, and several tetracyclic azetodiazepines which can be considered as potential compounds of biological interest have been prepared. Stereoselectivity of the cycloaddition was proved by NMR and X‐ray analysis data.
Durch Diels‐Alder‐Synthese werden aus den Cyclopentadienylsilanen (I) und Methyl(meth)acrylat (II) bei 80 ‐145°C die Addukte (III) in 52‐85%iger Ausbeute dargestellt.
Synthesis of 2-Methyl-1-[(5-methylfuran-2-yl)methyl]-and 2-Methyl--1-[(5-methylpyrrol-2-yl)methyl]-1H-benzimidazoles. -A straightforward route for the synthesis of the title furanylmethylbenzimidazoles (V) via cyclization of vicinal aminoanilides (IV) and its transformation into related pyrrolylmethylbenzimdazoles using a Paal-Knorr cyclization are described. -(STROGANOVA*, T. A.; RED'KIN, V. M.; KOVALENKO, G. A.; VASILIN, V. K.; KRAPIVIN, G. D.; Chem. Heterocycl.
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