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We report the case of a 41-year-oId woman with multiple cutaneous and uterine leiomyomata. The erythropoietic activity demonstrated in a cutaneous leiomyoma might account in part for her secondary erythrocytosis.The painful attacks were completely suppressed by phenoxybenzamine, an alpha adrenergic blocking agent.

We evaluated a patient in whom pachydermoperiostosis occurred in conjunction with anemia and gastric hypertrophy. The mechanism of the anemia appears multifactorial because, besides a myelofibrosis, a serum inhibitor of the late stage of erythropoiesis was detected. The elevated serum bone Gla-protein (osteocalcin) favors the hypothesis that primary hypertrophic osteoarthropathy represents an imbalance between increased osteoblastic bone formation and normal bone resorption.

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