42.8% including six PR in 14 patients in HR negatives. The ORR in HER2 positive (10 patients) and negative (24 patients) was 20% and 54.1%, respectively. The most common (>20% patients) treatment related adverse events were hand-foot syndrome (82.5%), fatigue (57.5%), nausea (47.5%), elevated liver enzymes (35%), vomiting (27.5%), mucositis (27.5%), diarrhea (22.5%), neutropenia (22.5%), anemia (22.5%). Most treatment related adverse events were grade1/2 in severity. None of the patients had a grade 3 adverse event and there were no patients with febrile neutropenia or treatment-related deaths. Grade 2 hand-foot syndrome was observed in only four patients (12.1%). Conclusions: In resource limited countries such as India, metronomic chemotherapy is an attractive option in anthracycline/taxane pretreated advanced breast cancer patients because of low cost, good tolerance, ease of administration and sound therapeutic efficacy.Legal entity responsible for the study: Madras Medical College Funding: None Disclosure: All authors have declared no conflicts of interest.113P Importance of immunohistochemistry for quick selection of breast cancer patients having BRCA1/2 mutations for their better treatment strategy: Pilot study in eastern India
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