Summary: A new method for water treatment utilizing radicals produced by a discharge on the surface of a bubble in water is proposed and this method is applied to the de‐color of indigo solution whose original color is blue. The discharge of this method begins at the crossing points of mesh electrode, acrylic resin spacer, and bubbling gas (i.e., called a triple junction where there is a weak point for the electrical breakdown in the electrical power devices). This weak point for the electrical breakdown is used very actively for the surface discharge. The discharge process on the surface of the bubble in water is also observed using a wire‐to‐plane electrode system to fix the observation region of discharge (type‐A reactor). The streamer length estimated by photographs increased linearly with the applied voltage. The energy consumption of discharge for type‐B reactor with a mesh‐to‐plane electrode in oxygen is about 0.09 J when the applied voltage is 20 kV. Production efficiency of the H2O2 concentration of about 27 mg · L−1 in oxygen (46 mg · L−1 in helium) has been obtained when the repetition rate of discharge operated by a pulsed‐power generator, the peak value of applied voltage, and the discharge period are 100 pps (pulsed power generator), 25 kV and 60 min, respectively.
This research program on the novel functions of Panax ginseng C. A. Meyer focused on the effects of ginseng rhizome on hair re-growth in androgenetic alopecia. Extracts of red ginseng rhizome showed greater dose-dependent inhibitory effects against testosterone 5α-reductase (5αR) when compared with extracts of the main root. Ginsenoside Ro, the predominant ginsenoside in the rhizome, and ginsenoside Rg(3), a unique ginsenoside in red ginseng, showed inhibitory activity against 5αR with IC(50) values of 259.4 and 86.1 µm, respectively. The rhizome of P. japonicus, which contains larger amounts of ginsenoside Ro, also inhibited 5αR. Topical administration of extracts of red ginseng rhizomes (2 mg/mouse) and ginsenoside Ro (0.2 mg/mouse) to shaved skin inhibited hair re-growth suppression after shaving in the testosterone-treated C57BL/6 mice. These results suggest that red ginseng rhizomes containing both oleanane- and dammarane-type ginsenosides are a promising raw material for cosmetic use. This is the first report that ginsenoside Ro enhances in vivo hair re-growth based on their inhibitory activity against 5αR in the androgenetic alopecia model.
An extract from red ginseng [steamed and dried roots of Panax ginseng C.A. Meyer (RGE)] has been shown to have various actions on physiological functions. The mechanisms by which RGE promotes cholesterol metabolism in the liver are unclear, but RGE decreases the plasma levels of cholesterol. We investigated whether RGE affected the mRNA expression of cholesterol metabolism-related proteins such as cytochrome P450 (CYP)7A1 and bile salt export pump (BSEP) in the liver in hypercholesterolemic rats and rat primary hepatocytes. In-vivo studies showed the upregulation of CYP7A1 mRNA in hypercholesterolemic rats treated with RGE. Treatment with RGE exhibited decreased ratios of low-density lipoprotein-cholesterol to high-density lipoprotein-cholesterol compared with hypercholesterolemia without RGE. In-vitro studies also showed the upregulation of CYP7A1 mRNA and protein levels by the addition of RGE to rat primary hepatocytes. The mRNA levels of BSEP exhibited few changes. The sustained levels of the liver X receptor (LXR) in vivo and the increased levels of LXR in vitro on RGE treatment could be involved in the upregulation of CYP7A1. To clarify the effects of 11 ginsenosides including RGE on the mRNA levels of CYP7A1 and BSEP, we performed in-vitro experiments using rat primary hepatocytes. The ginsenosides Ro, Rg3, Re, Rg1, and Rg2 exhibited increased mRNA levels of CYP7A1. These results suggest that several ginsenosides including RGE promoted cholesterol metabolism due to upregulation of CYP7A1.
Numerous pharmacological studies on Panax plants have been performed. However, these studies were limited to ginsenosides, which are typical constituents in Panax plants. In our research program to discover novel agents to prevent dementia and improve dementia symptoms, especially Alzheimer’s disease (AD), we investigated the inhibitory activities of essential oil (EO) extracts from 4 Panax plants against β-secretase, amyloid β (Aβ) aggregation, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). An EO extract of Panax japonicus showed the most potent activity with 51.3% inhibition at 500 μg/mL against β-secretase. Panax ginseng showed the most potent inhibitory activity against AChE and BChE with 70.4% and 84.4% inhibition at 50 μg/mL, respectively. Panax notoginseng extract showed the most potent activity with 57.3% inhibition at 500 μg/mL against Aβ aggregation. From these results, an EO extract of P. ginseng could be an effective agent to improve AD symptoms, while EO extracts of P. japonicus and P. notoginseng could be suitable for AD prevention.
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