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The anisotropic magnetoresistance (AMR) effect was systematically investigated in epitaxially grown Co 2 Fe x Mn 1−x Si films against Fe composition x and the annealing temperature. A change of sign in the AMR ratio from negative to positive was clearly detected when x increased from 0.6 to 0.8. This sign reversal can reasonably be explained by the change in the dominant s-d scattering process from s↑ → d↑ to s↑ → d↓ caused by the creation of large d-states at the Fermi level, suggesting the disappearance of half-metallicity at x = 0.8. The variations in the remanent density of states in the half-metallic gap against annealing temperature are also discussed from the viewpoint of the AMR ratio on the basis of the s-d scattering model.

Thrombotic cardio-cerebrovascular diseases seriously threaten human health. Currently, conventional thrombolytic treatments are challenged by the low utilization, inferior thrombus penetration, and high off-target bleeding risks of most thrombolytic drugs, resulting in unsatisfactory treatment outcomes. Herein, it is proposed that these challenges can be overcome by precisely integrating the conventional thrombolytic strategy with photothermal therapy. After co-assembly engineering optimization, a fibrin-targeting peptide-decorated nanoassembly of DiR (a photothermal probe) and ticagrelor (TGL, an antiplatelet drug) is prepared for thrombus-homing delivery, abbreviated as FT-DT NPs. The elaborately engineered nanoassembly shows multiple advantages, including simple preparation with high drug co-loading capacity, synchronous delivery of two drugs with long systemic circulation, thrombus-targeted accumulation with self-indicating function, as well as photothermal-potentiated thrombus penetration and thrombolysis with high therapeutic efficacy. As expected, FT-DT NPs not only show bright fluorescence signals in the embolized vessels, but also perform photothermal/antiplatelet synergistic thrombolysis in vivo. This study offers a simple and versatile co-delivery nanoplatform for imaging-guided photothermal/antiplatelet dual-modality thrombolysis.

FMEA, though valuable, is subject to certain limitations. In this study, FMEA failed to identify 17% of actual failure modes, though these were of lower risk. Similarly, an incident learning system alone fails to identify a large number of potentially high-severity process errors. Using FMEA in combination with incident learning may render an improved overview of risks within a process.

BackgroundLung adenocarcinoma (LUAD) is a highly mortal cancer. Tertiary lymphoid structures (TLS) are ectopic lymphoid organs with similar morphological and molecular characters to secondary lymphoid organ. The aim of this study is to investigate the prognostic effect of a gene signature associated with TLSs, including B-cell-specific genes.MethodsClinical data of 515 LUAD patients in the TGCA cohort were used to examine the relationship of TLS signature with immune microenvironment, tumor mutational burden (TMB), and driver gene mutations. Patients were divided into the TLS signature high group and TLS signature low group, and comparative analysis of survival and its influencing factors between the two groups was performed. The resulting data were then validated in the GSE37745 cohort.ResultsTLS signature high group had significantly better overall survival (OS) and progression-free interval (PFI) as well as significantly higher infiltration of immune cell subsets, cancer immune cycle (CIC) signature except for immunogram score2 (IGS2), and expression of major checkpoint genes than the TLS signature low group. Notably, while TLS signature was not markedly associated with TMB and mutation frequencies of driver genes, there were significant differences in overall survival of patients with given mutation status of EGFR, KRAS, BRAF and TP53 genes between the TLS signature high and low groups.ConclusionThis study provided evidence that LUAD patients with high TLS signature had a favorable immune microenvironment and better prognosis, suggesting that TLS signature is an independent positive prognostic factor for LUAD patients.

Ni-doped ZnO nanocrystals have been synthesized by a wet chemical reaction. The nanocrystals have been investigated carefully by high resolution transmission electron microscopy and all the particles are found to be the known wurtzite ZnO. X-ray photoelectron spectroscopy and Raman spectra results provide the evidence that Ni2+ is incorporated into the ZnO lattice at Zn2+ site. Magnetic property measurements reveal that the as-grown Zn1−xNixO nanocrystals exhibit room temperature ferromagnetic behaviors with saturation magnetization of 0.01emu∕g and Curie temperature above 340K for Ni concentration of ∼1% in atomic ratio.

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In this paper, the anisotropic magnetoresistance (AMR) effect was investigated to check the half-metallic/non-half-metallic nature of epitaxial Co2FeSi films. The evolution of the microstructure shows that the B2 and L21-ordering of Co2FeSi films will increase with increasing annealing temperature which causes a decrease of the d-states in the down-spin channel. When Co2FeSi films are annealed at 650 °C, better B2 and L21-ordering will change the dominant s-d scattering from s↑→d↓ to s↑→d↑. The change from a non-half-metallic to a half-metallic nature of the Co2FeSi films induces a sign change of the AMR ratio from positive to negative and a small value of the Gilbert constant (α = 0.0022).