Drug-related skin disorders may occur in many different ways. Despite pigmentary changes being less important for morbidity, these changes precipitate depressed mood and reduce self-confidence. Testosterone is a steroid hormone from the androgen group and primarily used for the treatment of hypogonadism in males. Testosterone replacement can cause skin problems like acne, hair loss, redness, pain, or infection at the injection site. The study was conducted on a 49-year-old man with adult onset idiopathic hypogonadotropic hypogonadism, which is an acquired form of isolated gonadotropin-releasing hormone deficiency. He was presented with lack of energy and decreased sexual function 10 years ago and was given an oil-based injectable blend of four esterized testosterone compounds as hormone replacement treatment in a urology polyclinic. He was referred to our polyclinic by endocrinologist because of progressive hyperpigmentation marked on his face and oral mucosa. In the present study, we report the first testosterone therapy-related facial and oral mucosal hyperpigmentation and acanthosis nigricans in the same patient.

Amyloidosis is a group disease which progresses with extracellular accumulation of fibrillary protein in beta conformation structure. It is categorized as localized amyloidosis when storage is limited to one organ (i.e. on skin) or systemic (generalized) amyloidosis when it occurs with several organ involvement. In this article, a primary systemic amyloidosis case diagnosed with skin lesions is presented with the purpose of reminding primary systemic amyloidosis in differential diagnosis of periorbital ecchymosis and reviewing the findings of primary systemic amyloidosis which is a rarely seen disease in dermatology practice.

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Kaposi's varicelliform eruption or eczema herpeticum is a viral infection developed on the grounds of a present skin disease. It is frequently seen on grounds of atopic dermatitis. Although it is generally related to herpes simplex virus type 1 and 2, rarely coxsackievirus or vaccinia virus play a role. In some patients, it threatens life by causing serious complications such as herpetic keratitis, encephalitis or sepsis. This case report presents a 4-month-old infant patient who was consulted by infant infection clinic for umblical vesicular eruption and who was diagnosed with Kaposi's varicelliform eruption and in whom encephalitis was detected. Following treatment, the patient was evaluated in terms of dermatologic diseases which might cause KVE and diagnosed with atopic dermatitis. Our purpose is to remind the Kaposi's varicelliform eruption which threatens life and might cause serious complications and in which early diagnosis and treatment are quite important and to emphasize the importance of investigating the underlying dermatologic disease. In addition, our case is the Kaposi's Varicelliform Eruption case which occurred at the youngest age which is reported in the literature.

Criyoglobulins are immunoglobulins that precipitate at low temperatures and dissolve at higher temperatures. The existence of cryoglobulins in serum is termed cryoglobulinaemia. Although, the patients with cryoglobulinaemia or cryoglobulinemic vasculitis, the consequence of cryoglobulinaemia, have typical symptoms related to the presence of cryoglobulins, may patients with cryoglobulinaemia remain asymptomatic. Criyoglobulinaemia a systemic vasculitis involving primarily small vessels, can be associated with infections, lymphoproliferative malignancies or autoimmune diseases. Type 1 criyoglobulins can be found in patients with , lymphoproliferative disorders, such as Waldernström macroglobulinaemia or multiple myelom, while mixt criyoglobulins are detected in patients with autoimmune diseases, lymphoproliferative disorders or infections, most commonly hepatitis C virus. We present a 38-year-old man with criyoglobulinemic vasculitis secondary to multiple myeloma. The patient was admitted to hospital with one year history of cutaneous purpura, aggrevated with cold, on his legs and ears accompanied by arthralgia. Skin biopsy revealed leukocytoclastic vasculitis. There was serum cryoglobulinaemia and serum immunofixation electropheresis showed a IgG kapa monoclonal gamapathy. Contrasted computed tomography evidenced osteolytic lesions on his 4th rip, biopsy of which demonstrated a plasmocytoma. The bone marrow biopsy yielded 90 % of kapa monoclonal plasma cells verifying the diagnosis of multiple myeloma.