A high‐yielding and high‐rate reduction method that operates with alkenes, alkynes, azides, nitriles, and nitroarenes was developed and optimized. The method makes use of sodium borohydride reduction of CoSO4 under release of hydrogen along with the formation of Co2B as a nanoparticle material. The produced Co2B activates the various functional groups for hydride reduction. The protocol was proven to operate with an assortment of functional groups to provide good to excellent yields. Furthermore, the reduction method was successfully adapted, implemented, and developed for a continuous flow approach using the multi‐jet oscillating disk (MJOD) flow reactor platform at atmospheric pressure.
A high rate, selective, and productive Appel type reaction was developed. The method allows for ipso-substitution of the alcoholic hydroxy group with halogens ∈ [ Cl, Br, I]. The method...
A concise improved method for the alkylation of the imidazole backbone has been developed. The positions 1 and 2 of the imidazole ring were protected with tetrahydro‐2H‐pyran‐2‐yl and chloro groups, respectively. Position 5 of imidazole was then lithiated, whereupon alkylation could be conducted by means of a variety of electrophilic reagents including haloalkanes, aldehydes, and ketones. Finally, the two protective / auxiliary groups on the positions 1 and 2 were easily removed by means of treatment with acid and base and hydrogenation, respectively. The developed method proved good functional group tolerance but demanded non‐bulky molecular moieties in the vicinity of the attaching C‐atom of the reagent. The novel alkylating method was used to synthesize two new NHC−Ag complexes holding branched alkyl groups on the imidazole backbone.
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