University of Mirnesota, l/Iinneapolis, Minnesota SYNOPSIS IN INTERLINGUA COMPONENTE PSYCHOLOGIC IN LE ETIOLOGIA DE LINGUA GEOGRAPIHIC.-SUb stress emotional, le linguas tle 11 afficite studentes se pejorava e illos de 4 se meliorava. Le profiles medie de MMPI (Inventorio Multiphasic de Personalitate Minnesota) de! afficite students esseva generalmente elevate in comparation con illos del subjectos de control. Duo de 35 subjectos de control e 15 de 35 afficite studentes habeva profiles de MMPI suggestive de disturbation psychologic. Le morbo esseva significativemente plus prevalence inter adults mentalmente malade que inter adultos normal o mentalmente deficiente. Iste evidentia mnonstra que stress emotional es un factor etiologic in lingua geographic, sed investigationes additional es necessari pro determinar su importantia relative.Geographic tongue (erylhema migrans), or wandering rash of the tongue, is a benign condition characterized by the appearance of discrete, reddened, smooth areas on the dorsal surface of the tongue. Over a period of days or weeks, the bald spots seem to migrate across the surface of the tongue by healing on one border and extending on another. The course of the disease varies in affected individuals from a pattern that is almost constantly present to spontaneous disappearance for varying periods of time.The pattern often attains a very striking appearance (Fig. 1) and has occasionally been mistaken for a serious condition, such as cancer. However, there is little doubt that it is completely benign.A number of etiologic factors have beenproposed, but none have been established.There were a number of investigations of geographic tongue in the late 19th century.Most of the observations and opinions expressed have not been appreciably improved upon since then. Among the etiologic factors proposed, emotional or nervous causes werePortions of this paper are based on a thesis submitted to the graduate faculty, University of Minnesota School of I)entistry in partial fulfillment of the requirements for the M.S.D. degree. Other portions were presented at the 42nd General Meeting of the IADR,
Carbonic anhydrase has been localized to the acini and ducts of mature rat salivary glands. This enzyme has been associated with ion transport, a prominent function of striated and excretory ducts in salivary glands, suggesting that it might be used as a marker of ductal differentiation. The purpose of this study was to immunohistochemically document developmental changes in carbonic anhydrase in the ducts of the rat sublingual and submandibular glands. Immunohistochemistry was performed with antibodies to human carbonic anhydrase isoenzymes I, II and VI on sections of sublingual and submandibular glands from rats at representative postnatal developmental ages. Reactions were weak in the ducts of both glands at 1 day, then progressively increased. By 42 days, reactions had the adult pattern of virtually none in the mucous or seromucous acini, moderate to strong in the striated and excretory ducts, and none to weak in the intercalated ducts. Weak to moderate reactions were observed in the granular convoluted tubules of the submandibular gland as they became recognizable at age 42 days. Reactions to carbonic anhydrase I and II antibodies also increased from none (1 day) to modest (42 days) in the demilunes of the sublingual gland. The order of reaction intensity of the antibodies was II > I > VI. When localized via these anti-human antibodies, carbonic anhydrase is a useful marker of the functional differentiation of the striated and excretory ducts of the developing rat sublingual and submandibular glands.
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