This Memorandum expresses the basic material balance relationships for the lung-blood-tissue gas transport and exchange system in a set of differential-difference equations containing a number of dependent time delays. Additional equations define the chemical details of transport and acid-base buffering, concentration equilibria, and blood flow behavior. Finally, a control func tFon is included defining the dependence of ventilation upon CSF (H), and arterial (H) and P at the carotid chenoceptors. A Fortran program was written for + I-O2 convenient digital simulation of the responses of the sys.tern to a wide variety of forcings, including C02 inhalation, hypoxia at: sea level, altitude hypoxia, and metabolic disturbances in acid-base balance. Both dynamic and steady-state behavior of the model were reasonably realistic.

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