The findings suggest that over-expression of TIF1γ occurs in early stages of colorectal carcinogenesis, is inversely related with Smad4 loss, and may be a prognostic indicator for poor outcome.
and prostate volume-adjusted [-2] proPSA (p2PSA)-related indices on prostate cancer (PC) and a clinically significant PC with more than 2 positive biopsy cores or high Gleason Grade Group in the PSA below 10 ng/mL (Clinical trial No. UMIN000016934).METHODS: Between April 2015 and March 2017, 421 men aged 50 to 79 who conducted 12 to 20-core prostate biopsy in the PSA range above age-specific cut-offs (3.0ng/ml, 3.5 ng/ml and 4.0 ng/ml, respectively, for age 50-64, 65-69 and 70-79) and below 10 ng/ml were registered in the PROPHET. Among those participants, 398 eligible men were investigated a diagnostic impact of various clinical laboratorybased free PSA-related and p2PSA-related indices on any grade, high volume and high Gleason grade group prostate cancer.RESULTS: Among 398 men, 179 (45%), 141 (35%) and 80 (20%) were diagnosed with any grade PC, Gleason grade group 2 and 3 PC, respectively. Total AUC-ROC, partial AUC-ROC above 90% sensitivity (J Urol. 2005; 173: 425) and false positive rate (FPR) at 90% sensitivity for PSA, free/total PSA (%f-PSA), p2PSA/%f-PSA and prostate health index (phi) are shown in Table 1. Impacts of those various clinical laboratory-based indices on distinguishing non PC vs PC, Grade Group 1/ positive biopsy cores 0-2 vs remaining higher grade/ volume PC and Grade Group 1-2/ positive biopsy cores 0-2 vs remaining higher grade/ volume PC are indicated in Table 1. The total AUC-ROC and partial AUC-ROC above 90% sensitivity were larger in p2PSA-related indices than using PSA and %f-PSA in any comparisons indicated in Table 1. The FPRs at 90% sensitivity in p2PSA/%f-PSA and phi were superior to those in PSA and %f-PSA in any comparisons. phi would avoid unnecessary biopsy in 38% of men with PSA between the age-specific cut-offs and 10 ng/ml in the setting for detecting Grade Group 3-5 cancer or positive biopsy cores >2.CONCLUSIONS: Clinical laboratory-based p2PSA-related indices would avoid in 35 to 41% of prostate biopsy in the setting not only for detecting any grade/ volume PC, but also for detecting clinically significant PC.
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