The capsule based DPI device is a low resistance device, suitable for use by patients with a wide range of COPD severities, delivering a consistent dose irrespective of disease severity and age. The device provided consistent delivery of indacaterol with no reported device failures in clinical trials.
The crystal structure of the low-temperature form of anhydrous caffeine has been determined by using X-ray powder-diffraction data with a combined simulated-annealing/Rietveld method. Anhydrous caffeine crystallizes with five crystallographically independent molecules in a monoclinic C-centred unit cell with dimensions of a=43.0390(17), b=15.0676(6) and c=6.95314(14) A and a beta angle of 99.027(2) degrees.
Crystals of NaZn(H2O)2[BP2O8].H2O were grown under mild hydrothermal conditions at 170 degrees C. The crystal structure (solved by X-ray single-crystal methods: hexagonal, P6(1)22 (no. 178), a = 946.2(2), c= 1583.5(1) pm, V= 1227.8(4).10(6) pm3, Z = 6) exhibits a chiral octahedral-tetrahedral framework related to the CZP topology and contains helical ribbons of corner-linked borate and phosphate tetrahedra. Investigation of the thermal behavior up to 180 degrees C shows a (reversible) dehydration process; this leads to the microporous compound Na[ZnBP2O8].H2O, which has the CZP topology. The crystal structure of Na[ZnBP2O8].H2O was determined by X-ray powder diffraction by using a combination of simulated annealing, lattice-energy minimization, and Rietveld refinement procedures (hexagonal, P6(1)22 (no. 178), a = 954.04(2), c = 1477.80(3) pm, V= 164.88(5).10(6) pm3, Z = 6). The essential structural difference caused by the dehydration concerns the coordination of Zn2- changing from octahedral to tetrahedral arrangement.
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