It takes two: Sugar diamino acids which differ from established sugar amino acids by an additional amino group provide access to novel branched oligosaccharide mimetics and a novel class of aminoglycoside mimetics such as 1. The latter are of great significance as potential ligands for new RNA targets emerging in the post‐genome era.
An efficient and simple two-step procedure for the formation of hydroxy-Freidinger lactams is presented. The methodology allows assembly of the cyclic threonine motif (cThr) in solution and on solid support during conventional peptide synthesis.
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