Tricho-dento-osseous (TDO) syndrome is an autosomal dominant disorder characterized by abnormalities of hair, teeth, and bone. We report on a family that seems to illustrate further clinical heterogeneity in the TDO syndrome. Although variable expression of a single TDO gene cannot be ruled out, the manifestations observed in this and other reported families appear to fall into distinct subtypes. This suggests the possibility that the clinical subtypes represent distinct genetic entities.
The tricho-dento-osseous syndrome (TDO syndrome) involves morphologic abnormalities of hair, teeth, and skeleton. Clinical findings of the TDO syndrome are excessively curly (fuzzy) hair, enamel hypoplasia, and skeletal findings of a generalized pattern of osseous sclerosis. We report an autosomal dominant syndrome with similar hair and teeth morphology, but with a skeletal dysplasia consisting of sclerosis and thickening of the calvarium with long bones that show subtle undertubulation but no sclerosis.
One hundred consecutive children with blunt esophageal foreign bodies were treated with a non-operative method of foreign body removal utilizing a Foley catheter. Dislodgement was successful in 98 children. There were no complications. Performed properly, the technique is rapid and safe. It precludes hospitalization and the slight hazards of endoscopy and general anesthesia.
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