Various derivatives of 5«-androst-l-ene have been prepared in the hope of obtaining compounds with high anabolic and minimal androgenic activity. The initial high order of biological activity in this series prompted the synthesis of other modifications. The preparation of 2«-methyl and 60-methyl-5«-androst-l-ene derivatives as well as a new method for the synthesis of the intermediate 2«-methyl-3-ketosteroids is described. Anabolic and androgenic activities of a number of these compounds are reported.

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Suinmnry ( f)-A8(12)-15-Dehydro-PGEl (III), ( j-)-A8(l2) could be separated from (V) by partition chromatography.Stereoselective reductions and an o p t i d resolution were thus achieved by these microbial processes.-PGEl (IV), and ( f)-15-efii-A8(l4-PGE, (V) have been synthesized from the readily available starting material (I} , and compound (111) has been stereoselectively reduced by micro-organisms to either (+)-or (-)-(V).

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