The purpose of the present experiment was to investigate the effect of a therapeutic manipulation of the feet and ankles on postural control during quiet standing in elderly adults. Seventeen elderly adults stood barefeet on a force platform and were asked to sway as little as possible. Within a trial, vision was suppressed by eyes closure. The task was executed in two experimental sessions: before and after a therapeutic manipulation of the feet and ankles. Centre of feet pressure (COP) displacements along the mediolateral (ML) and anteroposterior (AP) axes were recorded. For the two experimental sessions, subjects exhibited comparable COP displacements when vision was available and were similarly affected by the suppression of vision. However, when subjects had to adapt to the absence of vision within a 10s temporal frame, postural behaviour became different in the two experimental sessions: the sum of the ML and AP COP displacements increased within the 10s temporal frame before the therapeutic manipulation of the feet and ankles, whereas it remained unchanged after it. These results suggested that the therapeutic manipulation of the feet and ankles allows the elderly adults to partially compensate for the destabilising effect induced by the suppression of vision.
(1) range, variability and maximal instantaneous speed of the COP displacements decreased in the ML direction, whereas (2) they remained unchanged in the AP direction.
Conclusions.These results evidenced positive effects of mirror feedback on postural control in elderly adults that may put them at lower risks of falling.
Background
We applied for the first time 2 label-free technologies, physiological intermolecular modulation spectroscopy (PIMS) and nematic protein organization technic (NPOT) in anti-tumor necrosis factor (TNF) refractory inflammatory bowel disease (IBD) patients to identify clinical responders to vedolizumab therapy and elucidate their underlying functional molecular network.
Methods
PIMS analysis was performed in peripheral blood taken prior to the first vedolizumab application in 20 IBD patients (Crohn disease n = 13; ulcerative colitis n = 7) refractory to at least 1 previous anti-TNF agent therapy. Peripheral blood taken from clinical responders and nonresponders at week 14 of vedolizumab therapy were additionally subjected to NPOT analysis. Response to therapy was assessed by respective clinical disease activity scores (partial Mayo Score and Harvey–Bradshaw Index).
Results
Clinical response to vedolizumab treatment was observed in 7 of 13 Crohn disease and 4 of 7 ulcerative colitis patients at week 14. Response to therapy was accurately predicted by PIMS blood analysis in 100% of ulcerative colitis and 77% of Crohn disease patients. Overall prediction of clinical response with PIMS blood analysis was achieved with a 89% positive predictive value and a 82% negative predictive value. NPOT analysis revealed the heightened expression of the proteins ITGB7, ITGAV, ITG3, PF4, and ASGH in the peripheral blood of vedolizumab responders compared to nonresponders.
Conclusions
PIMS analysis of the blood of anti-TNF refractory IBD patients was able to stratify responders to vedolizumab therapy with high accuracy and specificity. NPOT technology could decipher underling molecular networks in the blood of responders, enabling subsequent personalized therapeutic approaches in IBD.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.