X-ray imaging is a widely used imaging modality in the medical diagnostic field due to its availability, low cost, high spatial resolution, and fast image acquisition. X-ray photons in standard X-ray sources are polychromatic. Detectors that allow to extract the "color" information of the individual X-rays can lead to contrast enhancement, improved material identification or reduction of beam hardening artifacts at the system level, if we compare them with the widely spread energy integrating detectors. Today, in the field of computed tomography (CT), prototypes of clinical grade systems based on spectral photon counting detectors are currently available for clinical research from different companies. One of the key system components in that development is the X-ray photon detector. This article reviews the photon detection hardware, from the conversion of X-rays into electrical signals to the pulse processing electronics. A review of available photon counting application specific integrated circuits (ASICs) for spectroscopic X-ray imaging is presented with emphasis on the CT medical imaging application.

Silicon photomultipliers can be used to infer the depth-of-interaction (DOI) in scintillator crystals. DOI can help to improve the quality of the positron emission tomography images affected by the parallax error. This paper contemplates the computation of DOI based on the standard deviation of the light distribution. The simulations have been carried out by GAMOS. The design of the proposed digital silicon photomultiplier (d-SiPM) with focal plane detection of the center of mass position and dispersion of the scintillation light is presented. The d-SiPM shares the same off-chip time-to-digital converter such that each pixel can be individually connected to it. A miniature d-SiPM 8×8 single-photon avalanche-diode (SPAD) array has been fabricated as a proof of concept. The SPADs along each row and column are connected through an OR combination technique. It has 256×256µm 2 without peripherals circuits and pads. The fill factor is about 11%. The average dark count rate of the mini d-SiPM is of 240kHz. The average photon detection efficiency is 5% at 480nm wavelength, room temperature and 0.9V excess voltage. The dynamic range is of 96dB. The sensor array features a time resolution of 212ps. The photon-timing SNR is 81dB. The focal plane statistics of the lightspot has been proved as well by measurements. Index Terms-single photon avalanche diode (SPAD), digital silicon photomultiplier (d-SiPM), time-of-flight (ToF), focal-plane processing, scintillation light spot dispersion

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