We present GENECODIS, a web-based tool that integrates different sources of information to search for annotations that frequently co-occur in a set of genes and rank them by statistical significance. The analysis of concurrent annotations provides significant information for the biologic interpretation of high-throughput experiments and may outperform the results of standard methods for the functional analysis of gene lists. GENECODIS is publicly available at http:// genecodis.dacya.ucm.es/.
GeneCodis is a web server application for functional analysis of gene lists that integrates different sources of information and finds modular patterns of interrelated annotations. This integrative approach has proved to be useful for the interpretation of high-throughput experiments and therefore a new version of the system has been developed to expand its functionality and scope. GeneCodis now expands the functional information with regulatory patterns and user-defined annotations, offering the possibility of integrating all sources of information in the same analysis. Traditional singular enrichment is now permitted and more organisms and gene identifiers have been added to the database. The application has been re-engineered to improve performance, accessibility and scalability. In addition, GeneCodis can now be accessed through a public SOAP web services interface, enabling users to perform analysis from their own scripts and workflows. The application is freely available at http://genecodis.dacya.ucm.es
Abstract-The widespread usage of the discrete wavelet transform (DWT) has motivated the development of fast DWT algorithms and their tuning on all sorts of computer systems. Several studies have compared the performance of the most popular schemes, known as Filter Bank Scheme (FBS) and Lifting Scheme (LS), and have always concluded that LS is the most efficient option. However, there is no such study on streaming processors such as modern Graphics Processing Units (GPUs). Current trends have transformed these devices into powerful stream processors with enough flexibility to perform intensive and complex floating-point calculations. The opportunities opened up by these platforms, as well as the growing popularity of the DWT within the computer graphics field, make a new performance comparison of great practical interest. Our study indicates that FBS outperforms LS in current-generation GPUs. In our experiments, the actual FBS gains range between 10 percent and 140 percent, depending on the problem size and the type and length of the wavelet filter. Moreover, design trends suggest higher gains in future-generation GPUs.
Background: In the Bioinformatics field, a great deal of interest has been given to Non-negative matrix factorization technique (NMF), due to its capability of providing new insights and relevant information about the complex latent relationships in experimental data sets. This method, and some of its variants, has been successfully applied to gene expression, sequence analysis, functional characterization of genes and text mining. Even if the interest on this technique by the bioinformatics community has been increased during the last few years, there are not many available simple standalone tools to specifically perform these types of data analysis in an integrated environment.
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