Despite extensive literature on content creators’ identities, strategies, and activities, there remains a gap in understanding how the constantly changing platform environment impacts their brand subjectivities. Against this backdrop, our article explores how evolutions in platforms—including constant updates to their affordances—shape the activities and interpretive processes of content creators. Drawing on interviews with 35 Chilean content creators in the field of fashion and lifestyle, along with an analysis of their Instagram images ( N = 165) and stories ( N = 150), we show how creators feel compelled to enact different versions of their brand subjectivities. Our findings show how creators experience platform changes based on three interrelated levels: in the form of communicative styles, as a sense of temporal acceleration, and as a constant negotiation with other actors in the social network through which commercial activities are configured. Thus, when platforms tend to make changes to improve their commercial viability, content creators have to adapt their brand subjectivities and practices across platforms and affordances. In addition to shedding light on the new routines and intensified economic pressures demanded of today’s digital workers, we also reveal how the ideal of creation has been supplanted with intensified competition amid constantly changing technological, social, and commercial ecologies.

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Objectives-Carotid intima-media thickness (cIMT) is an independent predictor of cardiovascular risk. Furthermore, ethnicity and gender-specific normative data are required to assess cIMT, which are not available for Andean-Hispanics. In addition, data regarding correlates of subclinical atherosclerosis in ethnic population are needed.Methods-We studied 1448 adults enrolled in a population-based study in Peru. cIMT and carotid plaque were measured with high-resolution ultrasonography. A healthy reference sample (n=472) with no cardiovascular disease, normal weight and normal metabolic parameters was selected to establish normative cIMT values. Correlates of abnormal cIMT and carotid plaque were assessed in the entire population.Results-In the reference sample, 95 th -percentile cIMT values were both age and genderdependent. In stepwise regression, selected predictors of increasing cIMT were: older age, impaired fasting glucose, diabetes mellitus, higher systolic blood pressure, higher LDL-cholesterol, smoking and male gender. Predictors of carotid plaque included older age, male gender, higher systolic blood pressure, lower diastolic blood pressure and higher LDL-cholesterol. HDL-cholesterol and Creactive protein were not associated with cIMT or carotid plaque. The lack of association with HDLcholesterol was confirmed using high performance liquid chromatography.© 2010 Elsevier Ireland Ltd. All rights reserved.Address for correspondence: Josefina Medina-Lezama, MD., Av. Cayma 401. Arequipa-Perú, Phone: +51-54-251518, Fax: +51-54-220838, jmedina@ucsm.edu.pe. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conflict of interest statementJunichiro Takahashi and Gen Toshima are employees of Skylight Biotech (Tokyo, Japan) which provide commercially available services for HPLC measurements of serum lipoproteins. The other authors have no conflicts of interest. NIH Public Access Author ManuscriptAtherosclerosis. Author manuscript; available in PMC 2011 August 1. Conclusions-We present ethnic-specific cutoffs for abnormal cIMT applicable to AndeanHispanics and correlates of subclinical atherosclerosis in this population. Pending longitudinal studies, our data supports several risk associations seen in other populations and can be used to identify Andean-Hispanics at increased risk for atherosclerotic cardiovascular disease. The lack of association between HDL-C and cIMT or carotid plaque in this population requires further investigation.

The SARS‐CoV‐2 global pandemic will disproportionately impact countries with weak economies and vulnerable populations including people with dementia. Latin American and Caribbean countries (LACs) are burdened with unstable economic development, fragile health systems, massive economic disparities, and a high prevalence of dementia. Here, we underscore the selective impact of SARS‐CoV‐2 on dementia among LACs, the specific strain on health systems devoted to dementia, and the subsequent effect of increasing inequalities among those with dementia in the region. Implementation of best practices for mitigation and containment faces particularly steep challenges in LACs. Based upon our consideration of these issues, we urgently call for a coordinated action plan, including the development of inexpensive mass testing and multilevel regional coordination for dementia care and related actions. Brain health diplomacy should lead to a shared and escalated response across the region, coordinating leadership, and triangulation between governments and international multilateral networks.

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