This is the second report on the continuing efforts of LAGID to increase the recognition and registration of patients with primary immunodeficiency diseases in 12 Latin American countries: Argentina, Brazil, Chile, Colombia, Costa Rica, Honduras, Mexico, Panama, Paraguay, Peru, Uruguay, and Venezuela. This report reveals that from a total of 3321 patients registered, the most common form of primary immunodeficiency disease was predominantly antibody deficiency (53.2%) with IgA deficiency reported as the most frequent phenotype. This category was followed by 22.6% other well-defined ID syndromes, 9.5% combined T- and B-cell inmunodeficiency, 8.6% phagocytic disorders, 3.3% diseases of immune dysregulation, and 2.8% complement deficiencies. All countries that participated in the first publication in 1998 reported an increase in registered primary immunodeficiency cases, ranging between 10 and 80%. A comparison of the estimated minimal incidence of X-linked agammaglobulinemia, chronic granulomatous disease, and severe combined immunodeficiency between the first report and the present one shows an increase in the reporting of these diseases in all countries. In this report, the estimated minimal incidence of chronic granulomatous disease was between 0.72 and 1.26 cases per 100,000 births in Argentina, Chile, Costa Rica, and Uruguay and the incidence of severe combined immunodeficiency was 1.28 and 3.79 per 100,000 births in Chile and Costa Rica, respectively. However, these diseases are underreported in other participating countries. In addition to a better diagnosis of primary immunodeficiency diseases, more work on improving the registration of patients by each participating country and by countries that have not yet joined LAGID is still needed.
Sexist attitudes have been claimed to play an important role in acceptability of intimate partner violence (IPV). Empirical evidence suggests that sexist individuals are also more accepting of violence in social relationships than non-sexist individuals. Results from multilevel regression models of data from 72,730 respondents of 51 countries around the world showed that (a) both sexism and acceptability of general violence in social relationships were positively related to acceptability of IPV and (b) the highest levels of acceptability of IPV were found among those sexist individuals who also present positive attitudes toward the use of violence in social relationships.
Objective: The influence of partners’ traditional gender role and partners’ level of general violence on intimate partner violence (IPV) against women has been studied separately most likely because they represent key aspects of apparently contrasting theoretical views. The main goal of the present study was to investigate the influence of both partners’ gender role and partners’ level of general violence on IPV against women. Method: Using data from 20,663 heterosexual women living with their partners from a probabilistic sample of 18- to 74-year-old women in the European Union, we investigated the association among physical and psychological IPV against women, partners’ traditional roles, and partners’ level of general violence. Results: The multilevel regression results indicated that, even after controlling for a number of interviewer, respondent, partner, and country-level characteristics, partners’ traditional gender role and partners’ level of general violence (main effects) were predictive of higher rates of physical and psychological IPV against women. Moreover, the greatest levels of IPV were observed in women who described their partners as both traditional and generally violent (interaction effect). Conclusions: The influence of partners’ traditional gender role and partners’ level of general violence on IPV against women has rarely been studied together most likely due to the apparently conflicting underlying theoretical assumptions. Our study provides empirical support for both views and suggests that intervention efforts focusing on both gender-based and non–gender-based violence are legitimate strategies for reducing the rates of IPV against women in society.
The revictimization of women during the life cycle has attracted the interest of many researchers in recent years. In this study, we examined the relationship between the experience of child abuse and the subsequent victimization by a male partner in adulthood. Specifically, we proposed that childhood abuse experiences negatively affect the development of healthy interpersonal relationships in adulthood. Thus, some female victims of child abuse are more likely to select potentially abusive intimate male partners. Data from 23,863 heterosexual women from the 28 countries of the European Union who were living with their partners at the time of the study were used. We investigated the association between child abuse, partner's adherence to traditional gender roles, and general violence and intimate partner violence (IPV) against women. Multilevel structural equation modeling (MSEM) results indicated that child abuse is positively related to the partner's traditional gender role and general violence, which in turn predict IPV. Countries' level of human development was found to affect this process. We found support for the hypothesis that child abuse is related to IPV partially because it influences partner selection in adulthood. Thus, when they become adults, girls abused in childhood tend to select partners who are either traditional or generally violent. There is a persistent influence of social structural conditions (i.e., country's human development) throughout this process.
Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) and other benzo-fused N-heterocycles constitute privileged structures found in numerous bioactive compounds. Thus, developing simple and selective syntheses to furnish these derivatives from easily accessible starting materials is an important and challenging goal. In this work, novel pyrrolobenzodiazepine and pyrroloquinazoline derivatives have been synthesized following a common two step synthetic strategy. This strategy involves a one-pot Ugi/cyclization sequence followed by a reduction with spontaneous thermocontrolled cyclization. The control of the temperature in this second step allows fully selective access to either pyrrolo[2,1-c][1,4]benzodiazepine-3-ones 6 or pyrrolo[2,1-b]quinazolines 7. Density functional theory (DFT) calculations have been carried out to rationalize this reactivity, identifying the kinetic and thermodynamic reaction products and offering insights into the cyclization pathways. These synthetic methodologies show the versatility of the Ugi reaction as a tool in the synthesis of heterocyclic compounds with a pseudopeptidic skeleton.
Sexual transmission has replaced intravenous drug use as the most common mechanism of HIV transmission. A large percentage of patients were simultaneously diagnosed with HIV and AIDS, indicating the need for new prevention strategies.
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The questionnaire was applied to 1945 fifth-, sixth-, seventh- and eighth-grade students (aged from 11 to 17 years), from 14 primary schools in Santo Domingo. Confirmatory factor analyses show that the seven-factor model (verbal violence among students, student verbal violence against teachers, direct physical violence and threats among students, indirect physical violence by students, social exclusion among students, disruptive behavior in the classroom, and teacher violence against students) offers a significantly better fit than the other models tested. After examining its psychometric properties, it was concluded that the presented version of the <em>CUVE<sup>3</sup>-EP</em> is a reliable and valid measure for the assessment of school violence in Dominican Republic primary schools. </p><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Normal" /> <w:LsdException Locked="false" Priority="9" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="heading 1" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 2" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 3" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 4" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 5" /> <w:LsdException Locked="false" 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