Objective To analyze the scientific production regarding maternal folic acid (FA) supplementation and its relationship with autistic spectrum disorder (ASD).
Data Sources We performed unrestricted electronic searches in the BIREME virtual bank, Virtual Health Library (VHL) and Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed) databases.
Selection of Studies For sample selection, articles that met the proposed objectives were included, published in English, Spanish and Portuguese, the use of Health Sciences Descriptors (DeCS): autistic OR autism AND autism spectrum disorder AND folic acid, AND, with the use of the Medical Subject Headings (MeSH): autistic OR autism AND autistic spectrum disorder AND folic acid.
Data Collection Data extraction was performed by the reviewers with a preestablished data collection formulary.
Data Synthesis The Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) was used based on a checklist with 27 items and a 4-step flowchart.
Results A total of 384 articles was found by the search strategies, of which 17 were eligible following the pre-established criteria. The main findings of the present review point to maternal FA supplementation in the pre-conception period and beginning of pregnancy as a protective effect in relation to ASD, which should be indicated in this period as prevention to the problem.
Conclusion According to the research analyzed, more studies are necessary to know its effects on pregnancy, since the consumption of excessive FA may not be innocuous.
Objective: To analyze the scientific literature on neonatal ophthalmia and its relation to the type of delivery and prevention methods.Method: Systematic review and meta-analysis with quantitative and qualitative approach based on the recommendations of the Cochrane Handbook. The databases were searched SciELO, LILACS and ME-DLINE/PubMed with use of descriptors in Decs neonatal ophthalmia, conjunctivitis, endophthalmitis and newborns and their descriptors in English present in the MeSH with the inclusion of case reports. Publications were selected between 2004 and 2014 in any language, complete with newborns and individuals diagnosed with neonatal ophthalmia. Studies were excluded if they had no information on the type of delivery and prevention methods.
Results:The relationship between vaginal and cesarean delivery have little statistical significance, while significant, when referring to the presence or absence of ophthalmia with OddsRatio (OR) 1.6, and confidence interval (CI) CI (0.168-15.2) and its relationship with preventive method (OR) 10.5 with CI (0.668 to 165.1). The overall result is not statistically significant although it may be considered presenting (OR) of 2.6 with IC (0.753 to 9.278) .
Conclusion:There is a significant relationship between mode of delivery, prevention and ophthalmia, the overall outcome of the metaanalysis demonstrated little negativity statistics which should be related to types of studies and quantities available that present enough reduced, highlighting the need for further studies.
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